15 documents found, page 1 of 2

Metabolic profiling of renal cell carcinoma tissue using gas chromatography met...

Background: Renal cell carcinoma (RCC) is marked by dysregulation of angiogenesis, energy metabolism, and nutrient sensing pathways [1]. This diversity is an obstacle to achieving long-term responses to treatment, notwithstanding progress in targeted and immunotherapeutic drugs. Objective: This study aimed to characterise the metabolic dysregulations that occur in RCC tissue using a metabolomics approach. Metho...

Mineral Content and Volatile Profiling of Prunus avium L. (Sweet Cherry) By-Pro...

Large amounts of Prunus avium L. by-products result from sweet cherry production and processing. This work aimed to evaluate the mineral content and volatile profiling of the cherry stems, leaves, and flowers of the Saco cultivar collected from the Fundão region (Portugal). A total of 18 minerals were determined by ICP-MS, namely 8 essential and 10 non-essential elements. Phosphorus (P) was the most abundant mi...

Mineral content and volatile profiling of Prunus avium L. (sweet cherry) y-Prod...

Large amounts of Prunus avium L. by-products result from sweet cherry production and processing. This work aimed to evaluate the mineral content and volatile profiling of the cherry stems, leaves, and flowers of the Saco cultivar collected from the Fundão region (Portugal). A total of 18 min erals were determined by ICP-MS, namely 8 essential and 10 non-essential elements. Phosphorus (P) was the most abundant m...

Differential cellular effects of sunitinib and pazopanib targeted drugs for met...

Urinary volatilomics unveils a candidate biomarker panel for noninvasive detect...

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer usually associated with asymptomatic development and risk of systemic progression. Hence, reliable molecular biomarkers of ccRCC are needed to provide early and minimally invasive detection. In this study, urinary volatilome profiling of patients diagnosed with ccRCC (n = 75), and cancer-free controls (n = 75), was performed to inv...

Impacto no metabolismo de células de carcinoma de células renais ao tratamento ...

Advances and perspectives in prostate cancer biomarker discovery in the last 5 ...

Prostate cancer (PCa) is the second most diagnosed cancer in men worldwide. For its screening, serum prostate specific antigen (PSA) test has been largely performed over the past decade, despite its lack of accuracy and inability to distinguish indolent from aggressive disease. Metabolomics has been widely applied in cancer biomarker discovery due to the well-known metabolic reprogramming characteristic of canc...

In vitro volatile exometabolome signature of clear cell renal cell carcinoma

Caracterização do exometaboloma volátil de linhas celulares de cancro renal com...

O Carcinoma de Células Renais (CCR) representa o terceiro cancro urológico mais frequente e letal em Portugal. Este tipo de cancro inclui vários subtipos histológicos com diferentes potenciais metastáticos, sendo o carcinoma de células claras (ccCCR) e o papilar (pCCR) os mais comuns. É atualmente reconhecida a importância da descoberta de biomarcadores moleculares específicos para o diagnóstico e estadiamento ...

Volatile metabolites as potential renal cell carcinoma biomarkers – an in vitro...