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Sequential T790M mutation testing and changes in the therapeutic approach after...
Estevinho, Fernanda; Silva, Ana Catarina; Cirnes, Luís; Amaro, TeresinaThe EGFR mutation is identified in 10-50% of patients with non-small cell lung cancer (NSCLC). After first-line therapy, with 1st or 2nd line tyrosinacinase (TKI) inhibitors, in patients with NSCLC and a sensitizing EGFR mutation the most frequent mechanism of resistance is the acquisition of a T790M mutation, in 50-70%. We present the clinical case of a woman with NSCLC, cT2bN1M1b, stage IV with cerebral and a...
Non-Secretory Multiple Myeloma with Patchy Marrow Involvement and Aberrant Cyto...
Silva, Miguel; Martins, Joana; Pinto, João; Amaro, TeresinaNon-secretory multiple myeloma is a rare form of the disease that presents a diagnostic challenge. A 69-year-old woman presented to the emergency department with a pathological fracture of the right clavicle, along with a history of asthenia and middle back pain in the preceding three months. Workup revealed multiple focal lytic bone lesions in the clavicles, ribs, skull and thoracic- lumbar-sacral spine, witho...
Hysteroscopic Findings Related with the Assessment and Treatment of Uterine Flo...
Peixinho, Catarina; Machado-Neves, Raquel; Silva, Pedro Tiago; Bernardes, João; Silva, Ana Catarina; Amaro, TeresinaIntroduction: Endosalpingiosis is a rare benign condition characterized by the presence of tubal epithelium outside the Fallopian tube. The clinical presentation of endosalpingiosis is nonspecific, and the diagnosis is typically incidental in women undergoing surgery for pelvic pain, infertility, urinary symptoms, or a pelvic mass. It can only be confirmed with histopathological examination.Case Report: We repo...
Pesquisa de mutação T790M sequencial e alteração da abordagem terapêutica após ...
Estevinho, Fernanda; Silva, Ana Catarina; Cirnes, Luís; Amaro, TeresinaA mutação do EGFR é identificada em 10 -50% dos doentes com cancro do pulmão de não pequenas células (CPNPC). Após terapêutica de primeira linha com inibidores da tirosinacinase (TKI) de 1.ª ou 2.ª linha, em doentes com CPNPC e mutação sensibilizadora do EGFR, o mecanismo de resistência mais frequente é a aquisição de mutação T790M, em 50 -70%. Apresenta -se o caso clínico de uma mulher com CPNPC, cT2bN1M1b, es...
Estrogen receptors in urogenital schistosomiasis and bladder cancer: Estrogen r...
Bernardo, Carina; Santos, Júlio; Costa, Céu; Tavares, Ana; Amaro, Teresina; Marques, Igor; Gouveia, Maria João; Félix, Vítor; Afreixo, VeraEstrogen-like metabolites have been identified in S. haematobium, the helminth parasite that causes urogenital schistosomiasis (UGS) and in patients´ blood and urine during UGS. Estrogen receptor (ER) activation is enriched in the luminal molecular subtype bladder cancer (BlaCa). To date, the significance of ER to these diseases remains elusive. We evaluated ERα and ERβ expression in UGS-related BlaCa (n = 27),...
Estrogen receptors in urogenital schistosomiasis and bladder cancer: estrogen r...
Bernardo, Carina; Santos, Júlio; Costa, Céu; Tavares, Ana; Amaro, Teresina; Marques, Igor; Gouveia, Maria João; Félix, Vítor; Afreixo, VeraEstrogen-like metabolites have been identified in S. haematobium, the helminth parasite that causes urogenital schistosomiasis (UGS) and in patients´ blood and urine during UGS. Estrogen receptor (ER) activation is enriched in the luminal molecular subtype bladder cancer (BlaCa). To date, the significance of ER to these diseases remains elusive. We evaluated ERα and ERβ expression in UGS-related BlaCa (n = 27),...
Metabolic coupling in urothelial bladder cancer compartments and its correlatio...
Afonso, Julieta; Santos, Lucio L.; Morais, Antonio; Amaro, Teresina; Longatto-Filho, Adhemar [UNESP]; Baltazar, FatimaMade available in DSpace on 2018-11-26T15:28:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-02-01; Life and Health Sciences Research Institute (ICVS) from the School of Health Sciences of the University of Minho; ICVS (reference ICVS-SSRL: ON.2 SR&TD Integrated Program); Monocarboxylate transporters (MCTs) are vital for intracellular pH homeostasis by extruding lactate from highly glycolytic cells. T...
Metabolic coupling in urothelial bladder cancer compartments and its correlatio...
Afonso, Julieta Alexandra Pereira; Santos, Lúcio L.; Morais, A.; Amaro, Teresina; Longatto Filho, Adhemar; Baltazar, Maria de Fátima MonginhoMonocarboxylate transporters (MCTs) are vital for intracellular pH homeostasis by extruding lactate from highly glycolytic cells. These molecules are key players of the metabolic reprogramming of cancer cells, and evidence indicates a potential contribution in urothelial bladder cancer (UBC) aggressiveness and chemoresistance. However, the specific role of MCTs in the metabolic compartmentalization within bladd...
Phospho-mTOR in non-tumour and tumour bladder urothelium: Pattern of expression...
Afonso, Julieta; Longatto-Filho, Adhemar [UNESP]; Da Silva, Vitor Moreira; Amaro, Teresina; Santos, Iucio L.Made available in DSpace on 2015-11-03T18:06:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-10-01. Added 1 bitstream(s) on 2015-11-04T10:13:22Z : No. of bitstreams: 1 WOS000342725400009.pdf: 652138 bytes, checksum: b4c7b188d4ab260cf65e7c3243e162c0 (MD5); Urothelial bladder carcinoma (UBC) is heterogeneous in its pathology and clinical behaviour. Evaluation of prognostic and predictive biomarkers is n...
The predominance of M2-polarized macrophages in the stroma of low-hypoxic bladd...
Lima, Luís; Oliveira, Daniela; Tavares, Ana; Amaro, Teresina; Cruz, Ricardo; Ferreira, José Alexandre; Santos, LúcioOBJECTIVE: Bacillus Calmette-Guérin (BCG) immunotherapy is the gold standard treatment for superficial bladder tumors with intermediate/high risk of recurrence or progression. However, approximately 30% of patients fail to respond to the treatment. Effective BCG therapy needs precise activation of the type 1 helper cells immune pathway. Tumor-associated macrophages (TAMs) often assume an immunoregulatory M2 phe...