2 documents found, page 1 of 1
The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA M...
Leal, Graciano; Comprido, Diogo; Luca, Pasqualino De; Morais, Eduardo Manuel Firmo; Rodrigues, Luís; Mele, Miranda; Santos, Ana R.; Costa, Rui O.Brain-derived neurotrophic factor (BDNF) is an important mediator of long-term synaptic potentiation (LTP) in the hippocampus. The local effects of BDNF depend on the activation of translation activity, which requires the delivery of transcripts to the synapse. In this work, we found that neuronal activity regulates the dendritic localization of the RNA-binding protein heterogeneous nuclear ribonucleoprotein K ...
Activity-dependent changes in the dendritic distribution of hnRNP K : functiona...
Morais, Eduardo Manuel FirmoDissertação de Mestrado em Biologia Celular e Molecular apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra.; Neurons communicate with each other through highly specialized structures, the synapses, and the synaptic strength can be bidirectionally modulated. Long-term potentiation (LTP) refers to a long-lasting enhancement of the excitatory synapse strength which may be induced by high-f...