4 documents found, page 1 of 1
Trypanocidal activity of flavonoids and limonoids isolated from Myrsinaceae and...
Leite,Ana C.; Placeres Neto,Artur; Ambrozin,Alessandra R. P.; Fernandes,João B.; Vieira,Paulo C.; Silva,Maria F. das G. F. da; de Albuquerque,SérgioThe activity of crude extracts of three Rapanea species (Myrsinaceae) and Cipadessa fruticosa (Meliaceae) was evaluated in vitro against the trypomastigote forms of Trypanosoma cruzi. Thirty-three extracts from different organs of these species were assayed and eleven of them showed significant activity (lysis % >50). The fractionation of an active extract from branches of R. lancifolia (99.5%) led to the isola...
Screening of Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogen...
Leite,Ana C.; Ambrozin,Alessandra R. P.; Castilho,Marcelo S.; Vieira,Paulo C.; Fernandes,João B.; Oliva,Glaucius; Silva,Maria Fátima das G. F. daThe inhibitory activity of crude extracts of Meliaceae and Rutaceae plants on glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) enzyme from Trypanosoma cruzi was evaluated at 100 μg/mL. Forty-six extracts were tested and fifteen of them showed significant inhibitory activity (IA % > 50). The majority of the assayed extracts of Meliaceae plants (Cedrela fissilis, Cipadessa fruticosa and Trichilia rama...
Limonoids from andiroba oil and Cedrela fissilis and their insecticidal activity
Ambrozin,Alessandra R. P.; Leite,Ana C.; Bueno,Fabiana C.; Vieira,Paulo C.; Fernandes,João B.; Bueno,Odair C.; Silva,M. Fátima das G. Fernandes daNine limonoids were isolated from Carapa guianensis and Cedrela fissilis. Among them, 1,2-dihydro-3beta-hydroxy-7-deacetoxy-7-oxogedunin is a new compound. Moreover, the assignments of some chemical shifts of xyloccensin k have been corrected and ¹H NMR data of 7-deacetylgedunin have been assigned for the first time. These isolated limonoids were assayed on Atta sexdens rubropilosa workers showing moderate inse...
New pyrone and quinoline alkaloid from Almeidea rubra and their trypanocidal ac...
Ambrozin,Alessandra R. P.; Mafezoli,Jair; Vieira,Paulo C.; Fernandes,João B.; Silva,M. Fátima das G. F. da; Ellena,Javier A.; Albuquerque,Sérgio deThe investigation of the ethyl acetate fraction of methanol extract from leaves of Almeidea rubra A. St.-Hil. (Rutaceae) afforded two new compounds 4-methoxy-6-[2-(methylamino)phenyl]-2H-pyran-2-one and rel-(7R,8R)-8-[(E)-3-hydroxy-3-methyl-1-butenyl]-4,8-dimethoxy-5,6,7,8 -tetrahydrofuro[2,3-b]quinoline-7-yl acetate, along with the known compounds arborinine, N-methyl-1-hydroxy-3-methoxyacridone, skimmianine, ...