2 documents found, page 1 of 1
Interaction of a Homologous Series of Amphiphiles with P-glycoprotein in a Memb...
Moreno, Maria João; Filipe, Hugo A. L.; Cunha, Susana V. P.; Ramos, Cristiana V.; Martins, Patricia A. T.; Abel, Biebele; Loura, Luís M. S.The transport of drugs by efflux transporters in biomembranes limits their bioavailability and is a major determinant of drug resistance development by cancer cells and pathogens. A large number of chemically dissimilar drugs are transported, and despite extensive studies, the molecular determinants of substrate specificity are still not well understood. In this work, we explore the role of polar and non-polar ...
Characterization of the Lipidome and Biophysical Properties of Membranes from H...
Moreno, Maria João; Martins, Patricia Alexandra Teles; Bernardino, Eva F.; Abel, Biebele; Ambudkar, Suresh VThe lipid composition of biomembranes influences the properties of the lipid bilayer and that of the proteins. In this study, the lipidome and the lipid/protein ratio of membranes from High Five™ insect cells overexpressing mouse P-glycoprotein was characterized. This provides a better understanding of the lipid environment in which P-glycoprotein is embedded, and thus of its functional and structural propertie...