2 documents found, page 1 of 1
Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphat...
Gerber, P. P.; Cabrini, M.; Jancic, C.; Paoletti, L.; Banchio, C.; von Bilderling, C.; Sigaut, L.; Pietrasanta, L. I.; Duette, G.; Freed, E. O.During the late stages of the HIV-1 replication cycle, the viral polyprotein Pr55(Gag) is recruited to the plasma membrane (PM), where it binds phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and directs HIV-1 assembly. We show that Rab27a controls the trafficking of late endosomes carrying phosphatidylinositol 4-kinase type 2 α (PI4KIIα) toward the PM of CD4(+) T cells. Hence, Rab27a promotes high levels of ...
Rab27a and Rab27b control different steps of the exosome secretion pathway
Ostrowski, M.; Carmo, NB.; Krumeich, S.; Fanget, I.; Raposo, G.; Savina, A.; Moita, CF.; Schauer, K.; Hume, AN.; Freitas, RP.; Goud, B.; Benaroch, P.Exosomes are secreted membrane vesicles that share structural and biochemical characteristics with intraluminal vesicles of multivesicular endosomes (MVEs). Exosomes could be involved in intercellular communication and in the pathogenesis of infectious and degenerative diseases. The molecular mechanisms of exosome biogenesis and secretion are, however, poorly understood. Using an RNA interference (RNAi) screen,...