17 documents found, page 1 of 2
Chitosan/alginate polyelectrolyte magnetic gel nanoarchitectonics with tunable ...
Veloso, Sérgio Rafael Silva; Vázquez-González, Margarita; Ribeiro, Mariana O.; Hilliou, L.; Amorim, Carlos O.; Amaral, Vítor S.Chitosan-based hydrogels hold promise as drug delivery systems for cancer therapy, but the poor mechanical properties often limit the biological application, requiring chemical cross-linking to improve sustained drug release. Besides, the addition of stimulus-responsiveness to chitosan requires chemical modifications that can further affect the gel properties. To overcome these challenges, in this work, a novel...
Elastic liposomes containing calcium/magnesium ferrite nanoparticles coupled wi...
Pacheco, Ana Rita Faria; Barros, Ana Margarida; Amorim, Carlos O.; Amaral, Vítor S.; Coutinho, Paulo J. G.; Rodrigues, Ana Rita OliveiraThis work reports on the design, development, and characterization of novel magneto-plasmonic elastic liposomes (MPELs) of DPPC:SP80 (85:15) containing Mg0.75Ca0.25Fe2O4 nanoparticles coupled with gold nanorods, for topical application of photothermal therapy (PTT). Both magnetic and plasmonic components were characterized regarding their structural, morphological, magnetic and photothermal properties. The magn...
Eco-friendly synthesis of fluorescent cobalt-doped manganese ferrites for therm...
Veloso, Sérgio R. S.; Nereu, Sara F.; Amorim, Carlos O.; Amaral, Vítor S.; Correa-Duarte, Miguel A.; Castanheira, Elisabete M. S.The synthesis of high-quality nanoparticles for biomedical applications through environmentally friendly methods is a major challenging task. In this work, oxidative precipitation and a novel method, oxidative hydrothermal synthesis, are explored as one-pot eco-friendly synthesis routes to obtain single phase multicore-like and single-core citrate-stabilized cobalt and/or manganese-doped ferrite (CoxMn1-xFe2O4,...
Synthesis of cobalt-doped manganese ferrites through eco-friendly methods for t...
Veloso, Sérgio Rafael Silva; Nereu, Sara F.; Amorim, Carlos O.; Amaral, Vítor S.; Correa-Duarte, M.; Castanheira, Elisabete M. S.In this work, multi- and single-core citrate-stabilized cobalt and/or manganese-doped ferrite (CoxMn1-xFe2O4, 0 ≤ x ≤ 1) nanoparticles were synthesized through eco-friendly methods: oxidative precipitation and oxidative hydrothermal synthesis.
Chitosan/alginate nanogels containing multicore magnetic nanoparticles for deli...
Veloso, Sérgio Rafael Silva; Marta, Eva S.; Rodrigues, Pedro V.; Moura, Cacilda; Amorim, Carlos O.; Amaral, Vítor S.; Correa-Duarte, Miguel A.In this study, multicore-like iron oxide (Fe3O4) and manganese ferrite (MnFe2O4) nanoparticles were synthesized and combined with nanogels based on chitosan and alginate to obtain a multimodal drug delivery system. The nanoparticles exhibited crystalline structures and displayed sizes of 20 ± 3 nm (Fe3O4) and 11 ± 2 nm (MnFe2O4). The Fe3O4 nanoparticles showed a higher saturation magnetization and heating effic...
Magnetoliposomes with calcium-doped magnesium ferrites anchored in the lipid su...
Cardoso, Beatriz Dias; Fernandes, Diana E. M.; Amorim, Carlos O.; Amaral, Vítor S.; Coutinho, Paulo J. G.; Rodrigues, Ana Rita OliveiraNanotechnology has provided a new insight into cancer treatment by enabling the development of nanocarriers for the encapsulation, transport, and controlled release of antitumor drugs at the target site. Among these nanocarriers, magnetic nanosystems have gained prominence. This work presents the design, development, and characterization of magnetoliposomes (MLs), wherein superparamagnetic nanoparticles are cou...
Magnetic nanosorbents of γ-polyglutamic acid for removing a β-blocker from water
Campos, Valquíria; Marques, Diego Gouveia; Nogueira, João; Amorim, Carlos O.; Daniel-da-Silva, Ana Luísa; Trindade, TitoMetoprolol is known as one of the most frequently used β-blockers to treat hypertension, however due to its widespread use and resistance to hydrolysis, concerning amounts of this medicine are found in surface waters, causing negative impacts on the environment and human health. To date, very few water treatment plants remove metoprolol due to the ineffectiveness of conventional procedures, thus indicating the ...
Oxidative precipitation synthesis of calcium-doped manganese ferrite nanopartic...
Veloso, Sérgio Rafael Silva; Andrade, Raquel G. D.; Gomes, Valéria; Amorim, Carlos O.; Amaral, Vítor S.; Salgueiriño, Verónica; Coutinho, Paulo J. G.Superparamagnetic nanoparticles are of high interest for therapeutic applications. In this work, nanoparticles of calcium-doped manganese ferrites (CaxMn1−xFe2O4) functionalized with citrate were synthesized through thermally assisted oxidative precipitation in aqueous media. The method provided well dispersed aqueous suspensions of nanoparticles through a one-pot synthesis, in which the temperature and Ca/Mn r...
Chemical strategies for dendritic magneto-plasmonic nanostructures applied to s...
Fernandes, Tiago; Nogueira, Helena I. S.; Amorim, Carlos O.; Amaral, João S.; Daniel-da-Silva, Ana L.; Trindade, TitoChemical analyses in the field using surface-enhanced Raman scattering (SERS) protocols are expected to be part of several analytical procedures applied to water quality monitoring. To date, these endeavors have been supported by developments in SERS substrate nanofabrication, instrumentation portability, and the internet of things. Here, we report distinct chemical strategies for preparing magneto-plasmonic (F...
Novel magnetoliposomes based on shape-anisotropic nanoparticles for combined ch...
Cardoso, Beatriz D.; Rodrigues, Ana Rita Oliveira; Bañobre-Lopez. M.; Almeida, B. G.; Amorim, Carlos O.; Amaral, V. S.; Coutinho, Paulo J. G.In this work, a new method for magnetoliposomes synthesis with improved and adequate structural, physicochemical and magnetic properties was developed. The overall results confirmed the development of a promising new method for the synthesis of cubic-shaped magnetic ferrite nanoparticles and a novel route for drug-loaded SMLs with improved features. The properties of these multifunctional nanosystems point to t...