5 documents found, page 1 of 1
Modulating inflammation through the neutralization of Interleukin-6 and tumor n...
Lima, Ana Cláudia Fernandes; Amorim, Diana Alexandra Silva; Laranjeira, Inês; Almeida, Armando; Reis, R. L.; Ferreira, Helena Susana Costa MachadoBiological agents that neutralize the activity of pro-inflammatory cytokines are revolutionizing the treatment of inflammatory conditions. However, the antibodies (Abs) short half-life and off-target distribution critically limit their efficacy and safety. Therefore, this work proposes the immobilization of anti-TNF-α and anti-IL-6 Abs at the surface of polymeric nanoparticles (NPs) in order to extend and incr...
Baccharis dracunculifolia decreases nociception, depressive-like behaviour and ...
Laranjeira, Inês; Apolinário, Elisabete; Amorim, Diana Alexandra Silva; Silva-Filho, Ademar; Pinto-Ribeiro, Filipa; Dias, Alberto Carlos PiresBackground: In arthritic disorders, inflammation and progressive degeneration of joints leads to the development of persistent pain and comorbid emotional impairments. Arthritis-induced peripheral sensitization leads to increased release of nociceptive molecules by primary afferents that activate neurones eglial cells in the spinal cord and supraspinal pain modulatory areas such as the amygdala (AMY) and the pe...
Minocycline reduces mechanical allodynia and depressive-like behaviour in type-...
Amorim, Diana Alexandra Silva; Puga, Sónia Andreia Silva; Bragança, Rui Pedro Rebelo; Braga, António José Falcão Peres; Pertovaara, AnttiA common and devastating complication of diabetes mellitus is painful diabetic neuropathy (PDN) that can be accompanied by emotional disorders such as depression. A few studies have suggested that minocycline that inhibits microglia may attenuate pain hypersensitivity in PDN. Moreover, a recent study reported that minocycline has an acute antidepressive-like effect in diabetic animals. Here we studied whether (...
Baccharis dracunculifolia decreases nociception, depressive-like behaviour and ...
Laranjeira, Inês; Apolinário, Elisabete; Amorim, Diana Alexandra Silva; Silva-Filho, Ademar; Pinto-Ribeiro, Filipa; Dias, Alberto Carlos PiresIn arthritic disorders both inflammation and the progressive degeneration of joints persistently activate nociceptors, in periarticular structures, leading to the development of persistent pain and comorbid emotional impairments. Arthritis-induced peripheral sensitization leads to increased release of nociceptive molecules by primary afferents that activate neurones e glial cells in the spinal cord and supraspi...
Metabotropic glutamate 5 receptor in the infralimbic cortex contributes to desc...
Pereira, Ana Carla David; Puga, Sónia Andreia Silva; Gonçalves, S.; Amorim, Diana Alexandra Silva; Silva, Carmen L. O.; Pertovaara, A.; Almeida, ArmandoThe involvement of the prefrontal cortex in pain processing has been recently addressed. We studied the role of the infralimbic cortex (IL) and group I metabotropic glutamate receptors (mGluRs) in descending modulation of nociception in control and monoarthritic (ARTH) conditions. Nociception was assessed using heat-induced paw withdrawal while drugs were microinjected in the IL of rats. Local anesthesia of the...