125 documents found, page 1 of 13
Breaking the virus: yeast glucans as an effective alternative to acyclovir in H...
Tavares-Valente, Diana; Moreira, Helena; Sousa, Pedro; Amorim, Manuela; Conde, António; Pintado, Manuela; Fernandes, João; Azevedo-Silva, JoãoGlucans, structural polysaccharides in the yeast cell wall, are known for their biological and immunomodulatory capacities, helping in prevention and management of infections. Herpes simplex virus type 1 (HSVI) is a prevalent infection that causes great comorbidity and is challenging to treat due to the adverse effects of standard antiviral drugs like acyclovir. This study assessed the potential of yeast glucan...
BRIDGING HIGHER AND BASIC EDUCATION: AN (INTER)ACTIVE LEARNING APPROACH TO HAND...
Karpyuk, António; Garcia, Bruna; Santos, Diana; Silva, Hugo; Amorim, Manuela; Lamas, Maria Céu; Mota, Sandra; Ferreira, StephanieWithin the scope of the undergraduate program in Biomedical Laboratory Sciences (from E2S, P. Porto), and in line with their future roles as healthcare professionals, it is essential to promote educational experiences that integrate technical-scientific knowledge with communication skills. The activity "Bridging Higher and Basic Education: (Inter)Active Learning on Hand Hygiene", designed and led by higher educ...
Comparative analysis of polysaccharide and nutritional composition of biologica...
Araújo-Rodrigues, Helena; Amorim, Manuela; Freitas, Victor de; Relvas, João B.; Tavaria, Freni K.; Pintado, ManuelaThis study chemically characterized three Pleurotus ostreatus fruiting bodies cultivated in the Iberian Peninsula under different conditions (biological and industrial), with emphasis on polysaccharide analysis. Comprehensive comparative data on cultivation-dependent nutritional variations will potentially improve their nutritional and therapeutic applications. Industrial mushrooms (POC and POA) contained signi...
Aprender genética: Uma abordagem interativa entre Ensino Superior e 1.º Ciclo d...
Novais, Gonçalo; Dias, Clara; Ferreira, Beatriz; Lamas, Maria Céu; Mota, Sandra; Amorim, Manuela; Amorim Sousa, Maria Manuela; Mota, SandraIntegrada na UC Educação Clínica II da E2S|Porto, foi desenvolvida uma intervenção educativa sobre hereditariedade, dirigida a 86 estudantes do 1.º ao 4.º ano do Ensino Básico (5-10 anos), em 4 sessões independentes com cerca de 45 minutos. Partindo da questão “Porque somos parecidos com os nossos pais?”, a atividade utilizou uma abordagem lúdico-pedagógica para explorar conceitos genéticos. Iniciou com a ident...
Purification of bioactive peptides from spent yeast autolysates
Oliveira, Ana Sofia; Pereira, Ana Margarida; Ferreira, Carlos M.H.; Pereira, Joana Odila; Amorim, Manuela; Faustino, Margarida; Durão, JoanaSpent brewer’s yeast have been described as an important source for bioactive peptides, with their properties well proven over the years. Besides the brewing sector, growing of large-scale processes on synthetic biology industry has generated a substantial amount of spent engineered yeast with further potential to be valued in a circular economy approach. In line with this perception, in this work, peptide-rich...
Biopolymer from Annona muricata residues as a potential sustainable raw materia...
Ramos, Igor F. S.; Dias, Samuel C.; Lopes, Talissa B. C.; Júnior, Francisco T. dos S. Silva; Araújo, Ricardo de; Gutierrez, Stanley J. C.Annona muricata is a fruit species belonging to the Annonaceae family, which is native to the warmer tropical areas of North and South America. A large amount of discarded residue from A. muricata is of interest for obtaining new industrial inputs. To propose the applications of the biopolymer from A. muricata residues (Biop_AmRs), this study aimed to characterize this input chemically and functionally, as well...
Fire-resistant bio-based polyurethane foams designed with two by-products deriv...
Capêto, Ana Paula; Amorim, Manuela; Sousa, Sérgio; Costa, Joana R.; Uribe, Braian; Guimarães, Ana Sofia; Pintado, Manuela; Oliveira, Ana L. S.There is a growing interest in replacing conventional fossil-based polymers and composites with waste-based materials and fillers for environmental sustainability. This study designed water-blown polyurethane rigid foams using two by-products from the Amyris fermentation process of producing β-farnesene. The distillation residue (FDR) served as the main polyol component in the foam’s formulation (PF), supplemen...
Circular economyeast: saccharomyces cerevisiae as a sustainable source of gluca...
Sousa, Pedro; Tavares-Valente, Diana; Pereira, Carla F.; Pinto-Ribeiro, Inês; Azevedo-Silva, João; Madureira, Raquel; Ramos, Óscar L.; Pintado, ManuelaGlucans, a polysaccharide naturally present in the yeast cell wall that can be obtained from side streams generated during the fermentation process, have gained increasing attention for their potential as a skin ingredient. Therefore, this study focused on the extraction method to isolate and purify water-insoluble glucans from two different Saccharomyces cerevisiae strains: an engineered strain obtained from s...
Exploring cannabidiol (CBD) and cannabigerol (CBG) safety profile and skincare ...
Luz-Veiga, Mariana; Mendes, Adélia; Tavares-Valente, Diana; Amorim, Manuela; Conde, António; Pintado, Manuela Estevez; Moreira, Helena R.Cannabinoids have long been known for their bioactive properties, with their topical application as anti-inflammatory compounds being at the forefront of research for the past decade. Concurrently, the cosmetic market is a fast-growing industry in constant need of new biomolecules. In this work, we studied the safety profile for topical applications of two cannabinoids: cannabidiol (CBD) and cannabigerol (CBG) ...
Exploring yeast glucans for vaccine enhancement: sustainable strategies for ove...
Azevedo-Silva, João; Amorim, Manuela; Tavares-Valente, Diana; Sousa, Pedro; Mohamath, Randolph; Voigt, Emily A.; Guderian, Jeffrey A.; Kinsey, RobertVaccine adjuvants are important for enhancing vaccine efficacy, and although aluminium salts (Alum) are the most used, their limited ability to induce specific immune responses has spurred the search for new adjuvants. However, many adjuvants fail during product development due to manufacturability, supply, stability, or safety concerns. This work hypothesizes that protein-free yeast glucans can be used as vacc...