3 documents found, page 1 of 1
Comparative study of humoral and cellular immunity against SARS-CoV-2 induced b...
Hasan, Zahra; Masood, Kiran Iqbal; Qaiser, Shama; Kanji, Akbar; Mwenda, Fridah; Alenquer, Marta; Iqbal, Junaid; Ferreira, Filipe; Wassan, YaqubWe investigated the effectiveness of different COVID-19 vaccinations administered in Pakistan by studying the effect of inactivated virus, mRNA and vector formulations. This study in 916 participants was conducted between October 2021 and July 2022. Subjects receiving inactivated (A), mRNA (B), one-dose vector (C), and two-dose vector (D) vaccines were sampled at baseline, 6, 12, and 24 weeks. Serum IgG antibod...
Pre-existing IgG antibodies to HCoVs NL63 and OC43 spike increased during the p...
Hasan, Zahra; Masood, Kiran Iqbal; Veldhoen, Marc; Qaiser, Shama; Alenquer, Marta; Akhtar, Mishgan; Balouch, Sadaf; Iqbal, Junaid; Wassan, YaqubPreexisting immunity may be associated with increased protection against non-related pathogens such as, SARS-CoV-2. There is little information regarding endemic human coronaviruses (HCOVs) from Pakistan, which experienced a relatively low COVID-19 morbidity and mortality. We investigated antibodies to SARS-CoV-2 and HCoVs NL63 and OC43, comparing sera from prepandemic controls (PPC) period with responses in he...
Mutation S110L of H1N1 Influenza Virus Hemagglutinin: A Potent Determinant of A...
Nieto, Amelia; Vasilijevic, Jasmina; Santos, Nuno Brito; Zamarreño, Noelia; López, Pablo; Amorim, Maria Joao; Falcon, AnaCharacterization of a pandemic 2009 H1N1 influenza virus isolated from a fatal case patient (F-IAV), showed the presence of three different mutations; potential determinants of its high pathogenicity that were located in the polymerase subunits (PB2 A221T and PA D529N) and the hemagglutinin (HA S110L). Recombinant viruses containing individually or in combination the polymerase mutations in the backbone of A/Ca...