22 documents found, page 1 of 3

Patterned glycopeptide-based supramolecular hydrogel promotes the alignment and...

The functional restoration of a damaged cardiac tissue relies on a synchronized contractile capacity of exogenous and/or endogenous cardiomyocytes, which is challenging to achieve. Here, we explored the potential of the short glycopeptide diphenylalanine glucosamine-6-sulfate (FFGlcN6S) conjugated with an aromatic moiety, namely fluorenylmethoxycarbonyl (Fmoc), to enhance cardiac tissue regeneration. At physiol...

Decellularized matrix-based hydrogel for targeted beta cell islet delivery in t...

Introduction: Type 1 Diabetes Mellitus (T1DM) affects over 9 million people worldwide and is marked by autoimmune destruction of pancreatic ?-cells, which produce insulin. Current treatment relies on exogenous insulin, but inaccurate delivery often causes poor glycemic control or hypoglycemia. Islet transplantation offers a promising alternative, though long-term graft survival remains a challenge. This work pr...

Decellularized cardiac tissue for the development of non-immunogenic EPSs-rich ...

Introduction: Cardiovascular diseases account for 32% of the global deaths, comprising different pathologies related to heart failure. The heart self-regeneration is limited, which is associated to the highest mortality and morbidity rates of cardiovascular diseases. To bridge this gap, we developed a decellularized extracellular matrix (dECM)-based cardiac patch functionalized with sulfated exopolysaccharides ...

Supercritical CO2-assisted decellularization: advanced pancreatic tissue platfo...

Introduction: Decellularization is a procedure that aims to remove the cellular and antigenic material of a tissue while preserving its extracellular matrix (ECM) and biological properties. Decellularized ECM offers a natural microenvironment with significant potential for use in cell-based therapies and tissue regeneration [1]. Different protocols have been employed to decellularize tissues and organs. However...

Bio-based hydrogel for beta cell islet transplantation in type 1 diabetes therapy

Objectives: Type 1 Diabetes Mellitus (T1DM) is a chronic autoimmune disease that destroys insulin-producing pancreatic cells, affecting over 9 million people globally. The primary treatment involves insulin therapy, but improper delivery can lead to poor glucose control or hypoglycemia. Pancreatic islet transplantation offers a potential alternative, but long-term graft survival remains a challenge. This study ...

Unlocking the potential of supercritical CO₂ for an efficient pancreatic tissue...

Introduction: Tissue decellularization is a procedure that removes cellular and antigenic material from specific tissues, while preserving the extracellular matrix (ECM), with conditions tailored to the tissue's properties. The decellularized ECM is a promising material for cell-based therapies or for tissue defect repair through the development of scaffolds and membranes, among others. Pancreas is an organ tha...

I-CARE: implantable decellularized-based cardiac patch for cardiac tissue repair

Introduction: Cardiovascular diseases account for 32% of the global deaths, comprising different pathologies related to heart failure. [1] The heart self-regeneration is limited, which is associated to the highest mortality and morbidity rates of cardiovascular diseases. The incapacity of endogenous regeneration reduces therapeutic approaches to the relief of symptoms rather than restoring the proper function o...

Melodic and vocal performance of school-aged children from disadvantaged backgr...

Fucoidan-coated silica nanoparticles promote the differentiation of human mesen...

Silica nanoparticles (SiNPs) are widely used in biomedical applications, such as cancer therapy/diagnosis or tissue engineering and regenerative medicine. Herein, we synthesized SiNPs and modified them with sulfonic acid groups (by organosilylation followed by oxidation) or a sulfated polysaccharide (i.e., fucoidan, a seaweed biopolymer, by using electrostatic surface immobilization) due to the known capacity o...

Psychometric properties of the portuguese version of the occupational fatigue e...

Reliable and valid instruments are essential for understanding fatigue in occupational settings. This study analyzed the psychometric properties of the Portuguese version of the Occupational Fatigue Exhaustion/Recovery (OFER). A cross-sectional study was conducted with 260 workers (M = 46.52 ± 13.16 years) from a textile industry, exposed to shift work. Convergent and discriminant validity, internal consistency...