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Atypical functional connectivity during unfamiliar music listening in children ...

Freitas, Carina; Hunt, Benjamin A. E.; Wong, Simeon M.; Ristic, Leanne; Fragiadakis, Susan; Chow, Stephanie; Iaboni, Alana; Brian, Jessica

Background: Atypical processing of unfamiliar, but less so familiar, stimuli has been described in Autism Spectrum Disorder (ASD), in particular in relation to face processing. We examined the construct of familiarity in ASD using familiar and unfamiliar songs, to investigate the link between familiarity and autism symptoms, such as repetitive behavior. Methods: Forty-eight children, 24 with ASD (21 males, mean...


Cortical gyrification morphology in individuals with ASD and ADHD across the li...

Gharehgazlou, Avideh; Freitas, Carina; Ameis, Stephanie H; Taylor, Margot J.; Lerch, Jason P.; Radua, Joaquim; Anagnostou, Evdokia

Autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) are common neurodevelopmental disorders (NDDs) that may impact brain maturation. A number of studies have examined cortical gyrification morphology in both NDDs. Here we review and when possible pool their results to better understand the shared and potentially disorder-specific gyrification features. We searched MEDLINE, PsycINF...


Neural correlates of familiarity in music listening: a systematic review and a ...

Freitas, Carina; Manzato, Enrica; Burini, Alessandra; Taylor, Margot J.; Lerch, Jason P.; Anagnostou, Evdokia

Familiarity in music has been reported as an important factor modulating emotional and hedonic responses in the brain. Familiarity and repetition may increase the liking of a piece of music, thus inducing positive emotions. Neuroimaging studies have focused on identifying the brain regions involved in the processing of familiar and unfamiliar musical stimuli. However, the use of different modalities and experim...


Polygenic transmission disequilibrium confirms that common and rare variation a...

Weiner, Daniel J.; Wigdor, Emilie M.; Ripke, Stephan; Walters, Raymond K.; Kosmicki, Jack A.; Grove, Jakob; Samocha, Kaitlin E.

Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of ASD cases, including those with strongly acting de novo variants, in which polygenic risk is relevant. Using a novel approach called the polygenic transmission disequilibrium test and data from 6,454 families with a child with ASD, ...


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