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Health-related quality of life at 5 years of age for children born very preterm...

Kim, SW; Tian, X; Andronis, L; Maier, RF; Varendi, H; Seppänen, A-V; Siljehav, V; Draper, ES; Zeitlin, J; Petrou, S; Seppänen, AV; El Rafei, R

Background: This study aimed to investigate the health-related quality of life (HRQoL) at 5 years of age of European children born very preterm across multi-dimensional outcomes by presence and severity of congenital anomalies. Methods: The study used data from a European cohort of children born very preterm (<32 weeks of gestation) and followed up to 5 years of age (N = 3493). Multilevel Ordinary Least Squares...


Motor-related health care for 5-year-old children born extremely preterm with m...

Costa, R; Aubert, AM; Seppänen, A-V; Ådén, U; Sarrechia, L; Zemlin, M; Cuttini, M; Männamaa, M; Pierrat, V; van Heijst, A; Barros, H; Johnson, S

Aim: To (1) determine the proportion of 5-year-old children born extremely preterm (EPT) with movement difficulties including cerebral palsy (CP) and the proportion of these children receiving motor-related health care (MRHC), and (2) describe factors associated with receiving MRHC. Method: Children born before 28 weeks’ gestation in 2011 to 2012 in 11 European countries were assessed with the Movement Assessme...


Cohort Profile: the Etude Epidémiologique sur les Petits Ages Gestationnels-2 (...

Lorthe, E; Benhammou, V; Marchand-Martin, L; Pierrat, V; Lebeaux, C; Durox, M; Goffinet, F; Kaminski, M; Ancel, PY; EPIPAGE-2 Study Group

Medical practices and the organization of care vary widely across countries and have markedly evolved over the past two decades. The prognosis of very preterm infants has changed accordingly, raising new questions and requiring new assessments. We therefore set up the EPIPAGE-2 cohort, a new longitudinal study of preterm infants, with the following objectives: to provide actualized estimates of short- and long-...


Maternal education and cognitive development in 15 European very-preterm birth ...

Sentenac, M; Benhammou, V; Aden, U; Ancel, PY; Bakker, LA; Bakoy, H; Barros, H; Baumann, N; Bilsteen, JF; Boerch, K; Croci, I; Cuttini, M; Draper, E

Background Studies are sparse and inconclusive about the association between maternal education and cognitive development among children born very preterm (VPT). Although this association is well established in the general population, questions remain about its magnitude among children born VPT whose risks of medical and developmental complications are high. We investigated the association of maternal education...


Priorities for collaborative research using very preterm birth cohorts

Zeitlin, J; Sentenac, M; Morgan, AS; Ancel, PY; Barros, H; Cuttini, M; Draper, E; Johnson, S; Lebeer, J; Maier, RF; Norman, M; Varendi, H

Objectives To develop research priorities on the consequences of very preterm (VPT) birth for the RECAP Preterm platform which brings together data from 23 European VPT birth cohorts. Design and setting This study used a two-round modified Delphi consensus process. Round 1 was based on 28 research themes related to childhood outcomes (<12 years) derived from consultations with cohort researchers. An external pa...


Neurodevelopment at 2 years and umbilical artery Doppler in cases of very prete...

Delorme, P; Kayem, G; Lorthe, E; Sentilhes, L; Zeitlin, J; Subtil, D; Rozé, JC; Vayssière, C; Durox, M; Ancel, PY; Pierrat, V; Goffinet, F

Objective To investigate the association between absent or reversed end-diastolic flow (ARED) on umbilical artery Doppler ultrasound and poor neurological outcome at 2 years of age after very preterm birth associated with suspected fetal growth restriction (FGR) or maternal hypertensive disorders. Methods The study population comprised all very preterm (22–31 completed weeks) singleton pregnancies delivered bec...


Association of Chorioamnionitis with Cerebral Palsy at Two Years after Spontane...

Maisonneuve, E; Lorthe, E; Torchin, H; Delorme, P; Devisme, L; L'Hélias, LF; Marret, S; Subtil, D; Bodeau-Livinec, F; Pierrat, V; Sentilhes, L

Objective. To assess whether chorioamnionitis is associated with cerebral palsy (CP) or death at 2 years' corrected age in infants born before 32 weeks of gestation after spontaneous birth. Study design. EPIPAGE-2 is a national, prospective, population-based cohort study of children born preterm in France in 2011; recruitment periods varied by gestational age. This analysis includes infants born alive after pre...


Early extubation is not associated with severe intraventricular hemorrhage in p...

Chevallier, M; Ancel, PY; Torchin, H; Marchand-Martin, L; Lorthe, E; Truffert, P; Jarreau, PH; Roze, JC; Pierrat, V; Marret, S; Baud, O; Benhammou, V

Objective To determine whether there is an association between severe intraventricular hemorrhage and early extubation in preterm infants born before 29 weeks of gestational age and intubated at birth. Methods This study included 1587 preterm infants from a nationwide French population cohort (EPIPAGE-2). Secondary data on intubated preterm infants were analyzed. After gestational age and propensity score match...


Planned Mode of Delivery of Preterm Twins and Neonatal and 2-Year Outcomes

Sentilhes, L; Lorthe, E; Marchand-Martin, L; Marret, S; Ancel, PY; Delorme, P; Goffinet, F; Quere, M; Kayem, G

OBJECTIVE: To assess neonatal and 2-year outcomes for preterm twins born after planned vaginal delivery compared with planned cesarean delivery. METHODS: Women with preterm cephalic first twins delivered after preterm labor or preterm prelabor rupture of membranes from 24 0/7 to 34 6/7 weeks of gestation, with both fetuses alive at the beginning of labor, were identified from the national prospective population...


Preterm premature rupture of membranes at 22-25 weeks' gestation: perinatal and...

Lorthe, E; Torchin, H; Delorme, P; Ancel, PY; Marchand-Martin, L; Foix-L'Helias, L; Benhammou, V; Gire, C; d'Ercole, C; Winer, N; Sentilhes, L

BACKGROUND: Most clinical guidelines state that with early preterm premature rupture of membranes, obstetric and pediatric teams must share a realistic and individualized appraisal of neonatal outcomes with parents and consider their wishes for all decisions. However, we currently lack reliable and relevant data, according to gestational age at rupture of membranes, to adequately counsel parents during pregnanc...


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