2 documents found, page 1 of 1
Using Portuguese BRCA pathogenic variation as a model to study the impact of hu...
Andaluz, Stephanie; Zhao, Bojin; Sinha, Siddharth; Lagniton, Philip Naderev Panuringan; Costa, Diogo Alpuim; Ding, Xiaofan; Brito, MiguelBackground: Admixture occurs between different ethnic human populations. The global colonization in recent centuries by Europeans led to the most significant admixture in human history. While admixture may enhance genetic diversity for better fitness, it may also impact on human health by transmitting genetic variants for disease susceptibility in the admixture population. The admixture by Portuguese global exp...
Combined TLR2/TLR4 activation equip non-mucosal dendritic cells to prime Th1 ce...
Zúquete, Sara; Ferreira, Mariana; Delgado, Inês L. S.; Gazalle, Paula; Andaluz, Stephanie; Rosa, Maria Teresa; Mendes, Ana Catarina; Santos, DulceActivated CD4+ T cells located at mucosal surfaces orchestrate local effector immune mechanisms. When properly polarized, these cells contribute to block infections at early stages and may be essential to restrain the local growth of mucosal tumors, playing a critical role in host protection. How CD4+ T cells simultaneously integrate gut-homing instructions and Th polarization signals transmitted by TLR-activat...