Made available in DSpace on 2022-04-29T08:46:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-05; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de Goiás; Cannabidiol (CBD) is a natural cannabinoid present in the Cannabis sativa plant, widely prescribed as an anticonvulsant drug, especially for pediatric use. However, its effects on male...
Made available in DSpace on 2022-04-29T08:46:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01; Objective: To investigate the bidirectional relationship by determining whether baseline sleep quality predicts pain intensity and whether baseline pain intensity predicts sleep quality in older individuals with chronic low back pain (LBP). Design: A prospective longitudinal cohort study with a 6-month ...
Studies have suggested the involvement of inflamma- tory processes in the physiopathology of bipolar disorder. Preclinical evidences have shown that histone deacetylase inhib- itors may act as mood-stabilizing agents and protect the brain in models of mania and depression. The aim of the present study was to evaluate the effects of sodium butyrate (SB) and valproate (VPA) on behavioral changes, histone deacetyl...
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OBJECTIVE: The aim of this study was to evaluate overall genetic damage induced by total sleep deprivation in obese, female Zucker rats of differing ages. METHOD: Lean and obese Zucker rats at 3, 6, and 15 months old were randomly distributed into two groups for each age group: home-cage control and sleep-deprived (N = 5/group). The sleep-deprived groups were deprived sleep by gentle handling for 6 hours, where...