2 documents found, page 1 of 1
Comprehensive molecular characterization of adenoid cystic carcinoma reveals tu...
Persson, Marta; Andersson, Mattias K.; Sahlin, Per‐Erik; Mitani, Yoshitsugu; Brandwein‐Weber, Margaret S.; Frierson Jr, Henry F.; Moskaluk, ChristopherAdenoid cystic carcinoma (ACC) is a MYB-driven head and neck malignancy with high rates of local recurrence and distant metastasis and poor long-term survival. New effective targeted therapies and clinically useful biomarkers for patient stratification are needed to improve ACC patient survival. Here, we present an integrated copy number and transcriptomic analysis of ACC to identify novel driver genes and prog...
Chromosome translocations, gene fusions, and their molecular consequences in pl...
Stenman, Göran; Fehr, Andre; Skálová, Alena; Vander Poorten, Vincent; Hellquist, Henrik; Mikkelsen, Lauge Hjorth; Saba, Nabil F.Salivary gland tumors are a heterogeneous group of tumors originating from the major and minor salivary glands. The pleomorphic adenoma (PA), which is the most common subtype, is a benign lesion showing a remarkable morphologic diversity and that, upon recurrence or malignant transformation, can cause significant clinical problems. Cytogenetic studies of >500 PAs have revealed a complex and recurrent pattern of...