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Chemogenetics with PSAM4-GlyR decreases excitability and epileptiform activity ...
Gonzalez-Ramos, Ana; Berglind, Fredrik; Kudláček, Jan; Ribeiro Rocha, Elza; Melin, Esbjörn; Sebastião, Ana M; Valente, Cláudia A.; Ledri, MarcoDespite the availability of new drugs on the clinics in recent years, drug-resistant epilepsy remains an unresolved challenge for healthcare, and one-third of epilepsy patients remain refractory to anti-seizure medications. Gene therapy in experimental models has emerged as effective treatment targeting specific neuronal populations in the epileptogenic focus. When combined with an external chemical activator u...
Date: 2024
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Origin: Repositório da Universidade de Lisboa