19 documents found, page 1 of 2
Validation of on-slide immunocytochemistry controls prepared from long-term pre...
Roque, Rúben Rodrigues; Srebotnik Kirbiš, Irena; Pinheiro, Carla Sofia Castro; Martins, Rita Sattler Fagulha; Tavares, Vanessa Sofia; André, SaudadeBACKGROUND: On-slide controls are essential for quality assurance in immunocytochemistry, yet their use in non-cell block cytology preparations remains a significant challenge. This study presents and evaluates a novel method for preparing on-slide controls from long-term prefixed cell suspensions, applicable to all types of cytology preparations. METHODS: A methodology for preparing on-slide controls is descri...
Targeting TNBC
Cruz, Adriana; Abreu, Bruna; Mendes, Cindy; Freitas-Dias, Catarina; Gonçalves, Filipe; Silva, Fernanda; Ramalho, José; André, SaudadeBreast carcinoma (BC) is the most common malignancy in women, with triple-negative breast cancer (TNBC) making up 10–20% of cases. TNBC has limited targeted therapies and poor survival due to late diagnosis and metastasis. Dendrimers are precise nanostructures with a three-dimensional globular architecture designed to target the negatively charged membranes of cancer cells. This study evaluated the anticancer p...
Neoplasia mesotelial maligna: relato de um caso
Anselmo, Beatriz; Correia, Sara; Tavares, Vanessa; André, Saudade; Mendonça, Paula; Roque, RubenO mesotelioma maligno é uma neoplasia rara e agressiva, com apresentação inicial assintomática, que resulta num diagnóstico tardio e tratamento frequentemente paliativo. Tornou-se mais relevante após a revolução industrial, pois está frequentemente associada à exposição prolongada a asbestos. Tem maior incidência em homens entre os 63 e 70 anos de idade e em 2020 detetaram-se em Portugal 79 novos casos e 73 mor...
Carcinossarcoma: estudo de caso em citologia ginecológica
Pinheiro, Carla; Bento, Ana; Freitas, Bárbara; Roque, Ruben; André, Saudade; Mendonça, PaulaO carcinossarcoma uterino, também conhecido por tumor mülleriano misto maligno, é um tumor raro em mulheres e tem um comportamento clínico agressivo. Corresponde a menos de 5% dos tumores malignos do corpo uterino, mas é responsável por 15-30% dos casos de morte em doentes com neoplasia maligna do útero. É uma neoplasia maligna bifásica caracterizada, histologicamente, por ser constituída por componente epiteli...
Metabolism-Targeted Therapy in NSCLC - A New Theranostics Inhalation Approach U...
Mendes, Cindy; Martins, Filipa; Granja, Sara; Gonçalves, Joana; Barros, Hélio; Casimiro, Teresa; Aguiar-Ricardo, Ana; Silva, Fernanda; Abreu, BrunaLung cancer is one of the most lethal cancers globally, primarily due to delayed diagnosis and lack of specific and effective therapy. Increased lactate production and consumption, along with cysteine metabolic reliance, are features identified in NSCLC in our recent studies. Cancer metabolic remodeling leads to excessive ROS production, triggering oxidative stress, promoting angiogenesis, causing cellular and ...
Metabolism-targeted therapy in NSCLC – A new theranostics inhalation approach u...
Mendes, Cindy; Martins, Filipa; Granja, Sara; Gonçalves, Joana; Barros, Hélio; Casimiro, Teresa; Ricardo, Ana Aguiar; Silva, Fernanda; Abreu, BrunaLung cancer is one of the most lethal cancers globally, primarily due to delayed diagnosis and lack of specific and effective therapy. Increased lactate production and consumption, along with cysteine metabolic reliance, are features identified in NSCLC in our recent studies. Cancer metabolic remodeling leads to excessive ROS production, triggering oxidative stress, promoting angiogenesis, causing cellular and ...
Metabolism-targeted therapy in NSCLC – A new theranostics inhalation approach u...
Mendes, Cindy; Martins, Filipa; Granja, Sara; Gonçalves, Joana; Barros, Hélio; Casimiro, Teresa; Aguiar-Ricardo, Ana; Silva, Fernanda; Abreu, BrunaLung cancer is one of the most lethal cancers globally, primarily due to delayed diagnosis and lack of specific and effective therapy. Increased lactate production and consumption, along with cysteine metabolic reliance, are features identified in NSCLC in our recent studies. Cancer metabolic remodeling leads to excessive ROS production, triggering oxidative stress, promoting angiogenesis, causing cellular and ...
Adjuvant Chemotherapy De-Escalation with Genomic Assay Protocol in Patients wit...
Martins-Branco, Diogo; Cristóvão Ferreira, Sofia; Gouveia, Emanuel; André, Saudade; Esteves, Susana; Brito, Margarida; Moreira, AntónioIntroduction: Genomic assays are useful tools for tailoring adjuvant treatment in early breast cancer. We aimed to analyse the role of an institutional protocol of a genomic assay for chemotherapy de-escalation.Methods: Prospective cohort study of all consecutive women diagnosed with hormone receptor-positive and human epidermal growth factor receptor 2-negative early breast cancer, tested with the 21-gene Recu...
Biópsia Mamária Assistida por Vácuo: Papel Diagnóstico e Terapêutico
Frade Santos, Sofia; Freire, Gonçalo; Doutel, Delfim; André, Saudade; Marques, José CarlosIntrodução A biópsia mamária assistida por vácuo (BAV) pode ter intenção diagnóstica e/ou terapêutica. Este estudo tem como objetivo a correlação imagiológica e anátomo-patológica de lesões submetidas a BAV. Material e Métodos Realizámos um estudo retrospetivo, que incluiu 221 BAV (guiadas por estereotaxia ou ecografia) efetuadas no Instituto Português de Oncologia de Lisboa/IPOLFG, num período de 15 meses. Ava...
Immunocytochemistry in lung fine needle aspiration cytology: comparison of four...
Santos, Bruna; Roque, Ruben; Pereira, Teresa; Mendonça, Paula; André, SaudadeBackground – Long-term preservation of fine-needle aspiration cytology slides is an essential requirement in cytopathology laboratories for the eventual performance of immunocytochemistry. ICQ contributes to a correct and complete diagnosis, considering that long-term morphological and antigenic preservation is essential to obtain reliable results. In this study, we intend to evaluate and compare the immunoexpr...