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Systematic UPLC-ESI-MS/MS study on the occurrence of staurosporine and derivati...
Andréo,Márcio A.; Jimenez,Paula C.; Siebra,Josy B. C. N.; Costa-Lotufo,Leticia V.; Vessecchi,Ricardo; Niehues,Michael; Lopes,João L. C.Former bioactivity-guided analysis of the marine invertebrate Eudistoma vannamei led to the isolation of staurosporine derivatives, which revealed strong cytotoxic activity against several human cancer cell lines. The occurrence of such alkaloids in E. vannamei may be correlated to the presence of associated biota, such as Streptomyces bacteria. In agreement to this hypothesis, marine microorganisms associated ...
Date: 2012
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Origin: Oasisbr