3 documents found, page 1 of 1
ATP Signaling Controlling Dyskinesia Through P2X7 Receptors
Fonteles, Analu A.; Neves, Julliana C. S.; Menezes, Ana Paula F.; Pereira, Juliana F.; Silva, Ana Thais A.; Cunha, Rodrigo A.; Andrade, Geanne M.Dopamine replacement therapy with L-3,4-dihydroxyphenylalanine (L-DOPA) is the only temporary therapy for Parkinson's disease (PD), but it triggers dyskinesia over time. Since dyskinesia is associated with increased neuronal firing that bolsters purinergic signaling, we now tested whether the selective and blood-brain barrier-permeable P2X7 receptor antagonist Brilliant Blue-G (BBG, 22.5-45 mg/kg ip) attenuated...
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Tr...
Canas, Paula M.; Porciúncula, Lisiane O.; Simões, Ana Patrícia; Augusto, Elisabete de Oliveira; Silva, Henrique B.; Machado, Nuno J.; Gonçalves, NélioNeurodegeneration is a process transversal to neuropsychiatric diseases and the understanding of its mechanisms should allow devising strategies to prevent this irreversible step in brain diseases. Neurodegeneration caused by seizures is a critical step in the aggravation of temporal lobe epilepsy, but its mechanisms remain undetermined. Convulsions trigger an elevation of extracellular adenosine and upregulate...
Blunted dynamics of adenosine A2A receptors is associated with increased suscep...
Rodrigues, Lisa; Miranda, Isabel M.; Andrade, Geanne M.; Mota, Marta; Cortes, Luísa; Rodrigues, Acácio G.; Cunha, Rodrigo A.; Gonçalves, TeresaOpportunistic gut infections and chronic inflammation, in particular due to overgrowth of Candida albicans present in the gut microbiota, are increasingly reported in the elder population. In aged, adult and young mice, we now compared the relative intestinal over-colonization by ingested C. albicans and their translocation to other organs, focusing on the role of adenosine A2A receptors that are a main stop si...