8 documents found, page 1 of 1
Atividades exercidas por bolsistas na Comissão de Ética para o Uso de Animais
Sampaio, Caroline Pinheiro Rocha; Sousa, Flaviana Castelo Branco Carvalho de; Andrade, Geanne Matos deA Comissão de Ética para o Uso de Animais (CEUA), é um órgão vinculado ao Departamento de Fisiologia e Farmacologia da Faculdade de Medicina da Universidade Federal do Ceará que regulariza o uso de animais experimentais em projetos de diversas áreas da UFC. Os bolsistas de iniciação acadêmica foram alocados no Comissão de ética para o Uso de Animais em um projeto multidisciplinar com o objetivo de organizar tod...
Behavioral, affective, and cognitive alterations induced by individual and comb...
Rabelo-da-Ponte, Francisco Diego; Gomes, Jessica Maria Pessoa; Torres, Nathércia Lima; Barbosa, João Ilo Coelho; Andrade, Geanne Matos deObjective: To evaluate whether exposing rats to individual or combined environmental stressors triggers endophenotypes related to mood and anxiety disorders, and whether this effect depends on the nature of the behavior (i.e., innate or learned). Methods: We conducted a three-phase experimental protocol. In phase I (baseline), animals subjected to mixed schedule of reinforcement were trained to press a lever wi...
Blockade of ATP P2X7 receptor enhances ischiatic nerve regeneration in mice fol...
Ribeiro, Tatianne; Oliveira, Júlia Teixeira; Almeida, Fernanda Martins; Tomaz, Marcelo Amorim; Melo, Paulo A.; Marques, Suelen AdrianiPreventing damage caused by nerve degeneration is a great challenge. There is a growing body of evidence implicating extracellular nucleotides and their P2 receptors in many pathophysiological mechanisms.In this work we aimed to investigate the effects of the administration of Brilliant Blue G (BBG) and Pyridoxalphosphate-6-azophenyl-20, 40 - disulphonic acid (PPADS), P2X7 and P2 non-selective receptor antagoni...
Pentoxifylline neuroprotective effects are possibly related to its anti-inflamm...
Neves, Kelly Rose Tavares; Nobre Júnior, Hélio Vitoriano; Leal, Luzia Kalyne Almeida Moreira; Andrade, Geanne Matos de; Brito, Gerly Anne de CastroPentoxifylline (PTX) is a phosphodiesterase inhibitor with anti-TNF-alpha activity, associated with its anti-inflammatory action. Considering Parkinson’s disease (PD) as a neuroinflammatory disorder, the objectives were to evaluate PTX neuroprotective properties, in a model of PD. Male Wistar rats, divided into sham-operated (SO), untreated 6-OHDA, and 6-OHDA treated with PTX (10, 25, and 50 mg/kg) groups, rece...
Synergistic effect of the flavonoid catechin, quercetin, or epigallocatechin ga...
Silva, Cecília Rocha da; Andrade Neto, João Batista de; Campos, Rosana de Sousa; Figueiredo, Narjara Silvestre; Sampaio, Letícia SerpaFlavonoids are a class of phenolic compounds commonly found in fruits, vegetables, grains, flowers, tea, and wine. They differ in their chemical structures and characteristics. Such compounds show various biological functions and have antioxidant, antimicrobial, anti-inflammatory, and antiapoptotic properties. The aim of this study was to evaluate the in vitro interactions of flavonoids with fluconazole against...
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms
Cruz, Giovany Michely Pinto da; Felipe, Cícero Francisco Bezerra; Scorza, Fúlvio Alexandre; Costa, Marta Aline Coelho da; Tavares, Alinne FariasPiperine, an alkaloid present in the Piper genus, was shown to have an anticonvulsant activity, evaluated by the pilocarpine-induced model, in mice. Pilocarpine (350 mg/kg, i.p.) was administered 30 min after piperine (2.5, 5, 10 and 20 mg/kg, i.p.) which significantly increased latencies to 1st convulsion and to death, and percentage of survivals. These parameters were also increased in the pilocarpine groups ...
Topical anti-inflammatory potential of Physalin E from Physalis angulata on exp...
Pinto, Natália Bitú; Morais, Talita Cavalcante; Carvalho, Karine Maria Martins Bezerra; Silva, Cecília Rocha; Andrade, Geanne Matos deThe anti-inflammatory effect of physalin E, a seco-steroid isolated from Physalis angulata L. was evaluated on acute and chronic models of dermatitis induced by 12-O-tetradecanoyl-phorbol-13- acetate (TPA) and oxazolone, respectively, in mouse ear. The changes in ear edema/thickness, production of pro-inflammatory cytokines (TNF- a and IFN- g ), myeloperoxidase (MPO) activity, and histological and immunohistoch...
Mangiferin ameliorates 6-hydroxydopamine- induced cytotoxicity and oxidative st...
Rao, Vietla Satyanarayana; Carvalho, Ana C. S.; Trevisan, Maria Teresa S.; Andrade, Geanne Matos de; Nobre Júnior, Hélio VitorianoMangiferin ameliorates 6-hydroxydopamine- induced cytotoxicity and oxidative stress in ketamine model of schizophrenia Vietla S. Rao 1 , Ana C. Carvalho 1 , Maria Teresa S. Trevisan 2 , Geanne M. Andrade 1 , Helio V. Nobre Júnior 1 , Manoel O. Moraes 1 , Hemerson I. Magalhães H. Iury 1 , Talita C. Morais 1 , Flavia A. Santos 1 1 Department of Physiology and Pharmacology, Federal University of Ceará, Cel Nunes d...