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PVP formulations of bis-cyclometalated iridium(III) complexes bearing β-modifie...

Cancer stands as the second leading global cause of death, following heart disease. Considering the severe side effects revealed by some chemotherapeutics for tumor treatment and anticancer therapies, the scientific community is actively exploring more effective alternatives. Photodynamic Therapy (PDT) mediated by porphyrin-based photosensitizers (PS) has emerged as an attractive alternative to more conventiona...

Development of catalyst-free approach to synthesize novel spiro[indoline-3,1′-p...

Spiro compounds are a class of naturally occurring organic molecules with a wide broad of applications in several fields, mainly in medicinal chemistry. Spirooxindoles have been considered by the scientific community as scaffolds for applications under medicinal purposes, namely as anticancer, antiviral, or antimicrobial agents. Due to this fact, the synthesis of spirocompounds, namely spirooxindoles is a hot t...

Carbon as a Natural Element, Chemistry and Life

Compostos de Tipo Porfirínico na Luta Contra Cancro e Microrganismos

Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosens...

In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2'-bipyridine)dichloroplatinum(II) and of the analogs' derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to gener...

Unraveling the photodynamic activity of cationic benzoporphyrin-based photosens...

In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2′-bipyridine)dichloroplatinum(II) and of the analogs’ derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to gener...

New triazine bridged triads based on BODIPY-porphyrin systems: extended absorpt...

Two novel triads connecting a BODIPY to ethylenediamine substituted porphyrins via triazine linker have been synthesized and characterized. One of the triads is a linear D-A structure with one BODIPY (D) and one porphyrin (A) bridged by the triazine linker and the other one is a branched A-D4 structure with the porphyrin core linked to four BODIPY units. The triads show extended absorption in the visible region...

Phthalocyanine-functionalized magnetic silica nanoparticles as anion chemosensors

Anionic species are one of the most common pollutants in residual and freshwaters. The presence of anthropogenic anions in water drastically increases the toxicity to living beings. Here, we report the preparation of a new optical active material based on tri(tosylamino)phthalocyanines grafted to ferromagnetic silica nanoparticles for anion detection and removal. The new unsymmetrical phthalocyanines (Pcs) prov...

Photocatalytic degradation of methyl orange mediated by a silica coated nanomag...

The photocatalytic activity of a silica coated nanomagnet porphyrin hybrid (NPH) and of the corresponding porphyrin precursors (H2P and ZnP) was evaluated in the degradation of the methyl orange dye (MO) under visible light irradiation. The catalytic degradation of MO was performed under air, in the absence and in the presence of aqueous hydrogen peroxide. The results show that the hybrid NPH was the most effec...

Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Ce...

Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of al...