37 documents found, page 1 of 4

In silica analysis of gad gene presence in classic and next-generation probiotics

Gamma-aminobutyric acid (GABA) is primarily produced in microbes through a GAD enzyme-mediated decarboxylation of L-glutamate, with pyridoxal 5’- phosphate (PLP) as a co-factor (Yogeswara et al., 2020). While studies have focused on pathogenic bacteria, metagenomic analysis shows gut-colonising bacteria also encode the gad gene. The GAD enzyme, encoded by gadA, gadB, or both, mediates GABA synthesis in bacteria...

Antifungal activity of Limosilactobacillus reuteri against Candida albicans and...

Background: Oral candidiasis is one of the most present fungal infections, with Candida albicans being the foremost responsible for this infection, but in recent years the non-Candida albicans Candida species play a significant role in the rise of cases of oral candidiasis [1]. Phenomena of resistance to regular antifungals are rising, which makes it harder to control cases of oral candidiasis. Thus, searching ...

Design and characterization of a cheese spread incorporating osmundea pinnatifi...

Marine algae have been emerging as natural sources of bioactive compounds, such as soluble dietary fibers and peptides, presenting special interest as ingredients for functional foods. This study developed a cheese spread incorporating red seaweed Osmundea pinnatifida extract and subsequently characterized it in terms of nutritional, pH, and microbiological parameters and bioactivities including prebiotic, anti...

Spray-drying encapsulation of the live biotherapeutic candidate Akkermansia muc...

Akkermansia muciniphila is regarded as a promising next-generation probiotic or live biotherapeutic candidate. Effective delivery strategies must be developed to ensure high enough viability of the probiotic strain throughout its industrial formulation, distribution chain, shelf-life, and, ultimately, the host’s gastrointestinal tract, where it should exert its beneficial effect(s). Among the possible methodolo...

Insights into the antimicrobial resistance profile of a next generation probiot...

Akkermansia muciniphila is a Gram-negative intestinal anaerobic bacterium recently proposed as a novel probiotic candidate to be incorporated in food and pharmaceutical forms. Despite its multiple health benefits, the data addressing its antimicrobial susceptibility profile remain scarce. However, the absence of acquired resistance in probiotic strains is a compulsory criterion for its approval in the qualified...

Propriedades de agregação e de biofilme de uma nova estirpe candidata a probiót...

Recentemente, a bactéria comensal intestinal Faecalibacterium duncaniae, anteriormente designada por Faecalibacterium prausnitzii, tem emergido como uma nova candidata a probiótico, apresentando bioatividades relevantes para o tratamento e prevenção de diversas doenças inflamatórias intestinais [1,2]. Apesar da sua elevada importância na saúde humana, a capacidade deste microrganismo para inibir a colonização p...

Revealing antimicrobial resistance profile of the novel probiotic candidate Fae...

Faecalibacterium prausnitzii, a resident anaerobic bacterium commonly found in healthy gut microbiota, has been proposed as a next generation probiotic with high potential for application in food matrices and pharmaceutical formulations. Despite its recognized health benefits, detailed information regarding its antimicrobial susceptibility profile is still lacking. However, this information is crucial to determ...

Viability of bifidobacterium animalis subsp. lactis BB-12® in chocolate matrice...

Effect of emulsification/internal gelation-based microencapsulation on the viab...

Akkermansia muciniphila is a common human intestinal commensal with a mucin-degrading nature. Its immunomodulatory characteristics and regulatory role of mucus layer and gut barrier integrity highlight the potential benefits of using this bacterium as an interventional player against inflammatory/cardio-metabolic disorders.In this work, we evaluate the effect of microencapsulation by the emulsification/internal...

Exploring freeze-drying as strategy to enhance viability of faecalibacterium du...

Faecalibacterium duncaniae is an intestinal commensal bacterium proposed as a next-generation probiotic due to its promising outcomes in the treatment and prevention of several human diseases, which demonstrate its multiple contributions to the host’s health. However, its strict anaerobic nature has created several hurdles in the development of functional foods, nutraceuticals, and biotherapeutic products. Here...