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Synthesis, Characterization, Bioavailability and Antimicrobial Studies of Cefur...
Faísca, Francisco; Petrovski, Željko; Grilo, Inês; Lima, Sofia A.C.; Santos, Miguel M.; Branco, Luis C.© 2024 by the authors. Licensee MDPI, Basel, Switzerland.; Low oral bioavailability is a common feature in most drugs, including antibiotics, due to low solubility in physiological media and inadequate cell permeability, which may limit their efficacy or restrict their administration in a clinical setting. Cefuroxime is usually administered in its prodrug form, cefuroxime axetil. However, its preparation requir...
Ionic Levothyroxine Formulations
Barreira, António; Santos, Andreia F. M.; Dionísio, Madalena; Jesus, Ana R.; Duarte, Ana Rita C.; Petrovski, Željko; Paninho, Ana B.; Ventura, Márcia G.Funding Information: Ana R. Jesus and Ana Rita C. Duarte acknowledge the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme, under grant agreement No ERC-2016-CoG 725034. Publisher Copyright: © 2023 by the authors.; Thyroid diseases affect a considerable portion of the population, with hypothyroidism being one of the most commonly reported thyroid diseases....
Novel Organic Salts Based on Mefloquine
Silva, Dário; Lopes, Márcio V. C.; Petrovski, Željko; Santos, Miguel M.; Santos, Jussevania P.; Yamada-Ogatta, Sueli F.; Bispo, Marcelle L. F.Funding Information: This work was supported by FCT-MCTES (PEst-C/LA0006/2013, RECI/BBBBQB/0230/2012). The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project N° 022161 (co-financed by FEDER through COMPETE 2020, POCI, PORL, and FCT through PIDDAC). Publisher Copyright: © 2022 by the authors.; The development of novel pharmaceutical tools to effic...
Enhanced In Vitro Antiviral Activity of Hydroxychloroquine Ionic Liquids agains...
Faísca, Francisco; Correia, Vanessa; Petrovski, Željko; Branco, Luís C.; Rebelo-de-Andrade, Helena; Santos, Miguel M.The authors also thank Fundação para a Ciência e Tecnologia for the projects Research 4 COVID-19 no. 582, and RECI/BBBBQB/0230/2012. The authors also acknowledge the Solchemar company. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.; The development of effective antiviral drugs against SARS-CoV-2 is urgently needed and a global health priority. In light of the initial data regardi...
Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata
Susano, Patrícia; Silva, Joana; Alves, Celso; Martins, Alice; Gaspar, Helena; Pinteus, Susete; Mouga, Teresa; Goettert, Márcia Ines; Petrovski, ŽeljkoUID/04292/2020 InSAICT-PAC/0019/2015-LISBOA-01-0145-FEDER-016405 POCI-01-0145-FEDER-029250; The ever-increasing interest in keeping a young appearance and healthy skin has leveraged the skincare industry. This, coupled together with the increased concern regarding the safety of synthetic products, has boosted the demand for new and safer natural ingredients. Accordingly, the aim of this study was to evaluate th...
Tailoring amphotericin B as an ionic liquid
Hartmann, Diego O.; Shimizu, Karina; Rothkegel, Maika; Petkovic, Marija; Ferraz, Ricardo; Petrovski, Željko; Branco, Luís C.; Canongia Lopes, José N.Funding Information: This work was nancially supported by Fundação para a Ciência e a Tecnologia (FCT) by Project MOSTMICRO ITQB with refs UIDB/04612/2020 and UIDP/04612/2020, and by the European Research Council through grant ERC 2014-CoG-647928. The authors thank FCT for funding the Research Unit Centro de Qúımica Estrutural (UIDB/00100/2020 and UIDP/00100/2020) and project PTDC/QUI-QFI/29527/2017, and PT202...
Highlighting the biological potential of the brown seaweed fucus spiralis for s...
Freitas, Rafaela; Martins, Alice; Silva, Joana; Alves, Celso; Pinteus, Susete; Alves, Joana; Teodoro, Fernando; Ribeiro, Helena MargaridaUID/MAR/04292/2020 PTDC/MAR-BIO/6149/2014 POCI-01-0145-FEDER-016791 SAICTPAC/0019/2015-LISBOA-01-0145-FEDER-016405 PTDC/BIA-OUT/29250/2017 POCI-01-0145-FEDER-029250 Centro-01-0145-FEDER-000018; Skin aging is a biological process influenced by intrinsic and extrinsic factors. The last ones, mainly exposure to UV radiation, increases reactive oxygen species (ROS) production leading to a loss of extracellular matr...
Marine Environmental Plastic Pollution: Mitigation by Microorganism Degradation...
Oliveira, Juliana; Belchior, Afonso; da Silva, Verônica D.; Rotter, Ana; Petrovski, Željko; Almeida, Pedro L.; Lourenço, Nídia D.; Gaudêncio, Susana P.UID/Multi/04378/2020 UID/CTM/50025/2020 Slovenian Research Agency (research core funding P1-0245); Plastics are very useful materials and present numerous advantages in the daily life of individuals and society. However, plastics are accumulating in the environment and due to their low biodegradability rate, this problem will persist for centuries. Until recently, oceans were treated as places to dispose of lit...
Synthesis and antibacterial activity of ionic liquids and organic salts based o...
Ferraz, Ricardo; Silva, Dário; Dias, Ana Rita; Dias, Vitorino; Santos, Miguel M.; Pinheiro, Luís; Prudêncio, Cristina; Noronha, João PauloFundacao para a Ciencia e Tecnologia through projects (PTDC/QUI-QOR/32406/2017, PEst-C/LA0006/2013) and PTDC/BTM-SAL/29786/2017, and one contract under Investigador FCT (L.C.B.). ZP thanks to Fundacao para a Ciencia e a Tecnologia, MCTES, for the Norma transitoria DL 57/2016 Program Contract. This work was also supported by the Associate Laboratory for Green Chemistry, which is financed by national funds from F...
Antimicrobial activities of highly bioavailable organic salts and ionic liquids...
Santos, Miguel M.; Alves, Celso; Silva, Joana; Florindo, Catarina; Costa, Alexandra; Petrovski, Željko; Marrucho, Isabel M.; Pedrosa, RuiUIDB/50006/2020 PTDC/QUI-QOR/32406/2017 PEst-C/LA0006/2013 RECI/BBBBQB/0230/2012; As the development of novel antibiotics has been at a halt for several decades, chemically enhancing existing drugs is a very promising approach to drug development. Herein, we report the preparation of twelve organic salts and ionic liquids (OSILs) from ciprofloxacin and norfloxacin as anions with enhanced antimicrobial activity....