8 documents found, page 1 of 1
Lactoferrin-loaded magnetic liposomes as potential photothermal agents for brea...
Andrade, Raquel G. D.; Santos-Pereira, Cátia; Ferreira, Débora Carina Gonçalves Abreu; Castanheira, Elisabete M. S.; Rodrigues, L. R.Nanoparticle-based drug delivery systems can afford an alternative treatment for breast cancer, overcoming conventional therapy’s limitations. In particular, superparamagnetic iron oxide nanoparticles entrapped in liposomes have gained significant interest in the biomedical field due to their exceptional properties, like enabling their accumulation at the intended target site when exposed to an external magneti...
Citrate-coated manganese and calcium ferrite nanoparticles as potential magneti...
Andrade, Raquel G. D.; Ferreira, Débora Carina Gonçalves Abreu; Veloso, Sérgio Rafael Silva; Santos-Pereira, Cátia; Castanheira, Elisabete M. S.In this work, manganese/calcium ferrite NPs coated with citrate, were synthesized by the sol-gel method, followed by calcination, and then characterized regarding their crystalline structure (by X-ray diffraction, XRD), size and shape (by Transmission Electron Microscopy, TEM), hydrodynamic size and zeta potential (by Dynamic Light Scattering, DLS), and heating efficiency (measuring the Specific Absorption Rate...
Magnetic lipid-based nanoparticles: recent advances in therapeutic applications
Andrade, Raquel G. D.; Veloso, Sérgio Rafael Silva; Castanheira, Elisabete M. S.; Rodrigues, L. R.In the realm of modern medicine, the pursuit of innovative solutions to enhance therapeutic applications has led to the exploration of cutting-edge technologies. The convergence of nanotechnology and medicine has marked a new era, where the scale of interventions has shifted to the molecular level. Nanoparticles with their ability to navigate through biological barriers, coupled with the potential for targeted ...
Oxidative precipitation synthesis of calcium-doped manganese ferrite nanopartic...
Veloso, Sérgio Rafael Silva; Andrade, Raquel G. D.; Gomes, Valéria; Amorim, Carlos O.; Amaral, Vítor S.; Salgueiriño, Verónica; Coutinho, Paulo J. G.Superparamagnetic nanoparticles are of high interest for therapeutic applications. In this work, nanoparticles of calcium-doped manganese ferrites (CaxMn1−xFe2O4) functionalized with citrate were synthesized through thermally assisted oxidative precipitation in aqueous media. The method provided well dispersed aqueous suspensions of nanoparticles through a one-pot synthesis, in which the temperature and Ca/Mn r...
Review on the advancements of magnetic gels: towards multifunctional magnetic l...
Veloso, Sérgio R. S.; Andrade, Raquel G. D.; Castanheira, Elisabete M. S.Magnetic gels have been gaining great attention in nanomedicine, as they combine features of hydrogels and magnetic nanoparticles into a single system. The incorporation of liposomes in magnetic gels further leads to a more robust multifunctional system enabling more functions and spatiotemporal control required for biomedical applications, which includes on-demand drug release. In this review, magnetic gels co...
Magnetoliposomes: recent advances in the field of controlled drug delivery
Veloso, Sérgio Rafael Silva; Andrade, Raquel G. D.; Castanheira, Elisabete M. S.Magnetoliposomes have gained increasing attention as delivery systems, as they surpass many limitations associated with liposomes. The combination with magnetic nanoparticles provides a means for development of multimodal and multifunctional theranostic agents that enable on-demand drug release and real-time monitoring of therapy.
Magnetoliposomes incorporated in peptide-based hydrogels: towards development o...
Veloso, Sérgio Rafael Silva; Andrade, Raquel G. D.; Ribeiro, Beatriz C.; Ferreira, André V. F.; Rodrigues, Ana Rita Oliveira; Martins, J. A. R.A major problem with magnetogels is the encapsulation of hydrophobic drugs. Magnetoliposomes not only provide these domains but also improve drug stability and avert the aggregation of the magnetic nanoparticles. In this work, two magnetoliposome architectures, solid and aqueous, were combined with supramolecular peptide-based hydrogels, which are of biomedical interest owing to their biocompatibility, easy tun...
Shape anisotropic iron oxide-based magnetic nanoparticles: synthesis and biomed...
Andrade, Raquel G. D.; Veloso, Sérgio R. S.; Castanheira, Elisabete M. S.Research on iron oxide-based magnetic nanoparticles and their clinical use has been, so far, mainly focused on the spherical shape. However, efforts have been made to develop synthetic routes that produce different anisotropic shapes not only in magnetite nanoparticles, but also in other ferrites, as their magnetic behavior and biological activity can be improved by controlling the shape. Ferrite nanoparticles ...