17 documents found, page 1 of 2

HepatoPredict Accurately Selects Hepatocellular Carcinoma Patients for Liver Tr...

Background/objectives: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths rising worldwide. This is leading to an increased demand for liver transplantation (LT), the most effective treatment for HCC in its initial stages. However, current patient selection criteria are limited in predicting recurrence and raise ethical concerns about equitable access to care. This study aims to enhance pa...

HepatoPredict Accurately Selects Hepatocellular Carcinoma Patients for Liver Tr...

Publisher Copyright: © 2025 by the authors.; Background/Objectives: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths rising worldwide. This is leading to an increased demand for liver transplantation (LT), the most effective treatment for HCC in its initial stages. However, current patient selection criteria are limited in predicting recurrence and raise ethical concerns about equitable ...

Vacinação Extra-PNV: a realidade de uma USF

   Introdução: A vacinas são a melhor arma preventiva para muitas doenças. Apesar de Portugal ser um dos países com maior taxa de cobertura vacinal para as imunizações do Programa Nacional de Vacinação (PNV), o mesmo não acontece com as imunizações extra PNV. Em várias USF, o aconselhamento e o esclarecimento sobre estas vacinas é muito heterogéneo e varia consoante o profissional. Existem estudos que demonstra...

Comentário ao acórdão do tribunal de justiça da União Europeia, de 22 de setemb...

Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associa...

Coffee may protect against non-alcoholic fatty liver disease (NAFLD), but the roles of the caffeine and non-caffeine components are unclear. Coffee intake by 156 overweight subjects (87% with Type-2-Diabetes, T2D) was assessed via a questionnaire, with 98 subjects (all T2D) also providing a 24 h urine sample for quantification of coffee metabolites by LC-MS/MS. NAFLD was characterized by the fatty liver index (...

Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associa...

Coffee may protect against non-alcoholic fatty liver disease (NAFLD), but the roles of the caffeine and non-caffeine components are unclear. Coffee intake by 156 overweight subjects (87% with Type-2-Diabetes, T2D) was assessed via a questionnaire, with 98 subjects (all T2D) also providing a 24 h urine sample for quantification of coffee metabolites by LC-MS/MS. NAFLD was characterized by the fatty liver index (...

Impact of blinded retrospective continuous glucose monitoring on clinical decis...

Background and aims: Blinded retrospective continuous glucose monitoring (rCGM) provides detailed information about real-life glycaemic profile. In persons with type 2 diabetes without adequate glycaemic control, the structured introduction of rCGM may be beneficial to sustain improvements in diabetes management. Methods and results: 102 individuals with insulin-treated type 2 diabetes, age less than 66 years o...

Loss of postprandial insulin clearance control by Insulin-degrading enzyme driv...

Systemic insulin availability is determined by a balance between beta-cell secretion capacity and insulin clearance (IC). Insulin-degrading enzyme (IDE) is involved in the intracellular mechanisms underlying IC. The liver is a major player in IC control yet the role of hepatic IDE in glucose and lipid homeostasis remains unexplored. We hypothesized that IDE governs postprandial IC and hepatic IDE dysfunction am...

Critical factors for benefits realisation in collaborative university-industry ...

This study aims to help academics and practitioners to realise the benefits resulting from collaborative university-industry research and development (R&D), by identifying the most critical factors for benefits’ realisation. A literature review was conducted allowing us to compile a list of 33 most acknowledged benefits resulting from university-industry R&D collaborations, and a list of 66 critical factors for...

Effectiveness of high-intensity interval training combined with resistance trai...

Aims: To evaluate the impact of one-year high intensity interval training (HIIT) combined with resistance training (RT) vs continuous moderate intensity training (MCT) combined with RT on glycaemic control, body composition and cardiorespiratory fitness (CRF) in patients with type 2 diabetes. Materials and Methods: A randomized controlled trial included 96 participants with type 2 diabetes for a one-year superv...