Ketamine (KET) is an N-methyl-D-aspartate (NMDA) antagonist with rapid and long-lasting antidepressant effects, but how the drug shows its sustained effects is still a matter of controversy. The objectives were to evaluate the mechanisms for KET rapid (30 min) and long-lasting (15 and 30 days after) antidepressant effects in mice. A single dose of KET (2, 5, or 10 mg/kg, po) was administered to male Swiss mice ...
Made available in DSpace on 2019-10-04T12:31:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-10-01; Introduction. - We investigated the associations between total and different domains of physical activity and resting heart rate in adolescents. Summary of facts and results. - The sample was composed of 716 girls and 515 boys aged between 14 to 17 (15.55 +/- 1.07) years. Resting heart rate was evaluate...