11 documents found, page 1 of 2
The benefit of HER2-targeted therapies on overall survival of patients with met...
Mendes, Diogo; Alves, Carlos; Afonso, Noémia; Cardoso, Fátima; Passos-Coelho, José Luís; Costa, Luís; Andrade, Sofia; Batel-Marques, FranciscoIntroduction: This study aimed at evaluating the overall survival (OS) gain associated with human epidermal growth factor receptor 2 (HER2)-directed therapies in patients with metastatic breast cancer (mBC). Methods: A bibliographic search was conducted in PubMed and Cochrane databases. Only phase III randomized controlled trials (RCTs) including HER2-positive (HER2+) mBC patients were included in this review. ...
A atitude do educador de infância e a participação da criança como referenciais...
Luís, Joana Freitas; Andrade, Sofia; Santos, Paula CoelhoNeste artigo, fundamentado em dois estudos de caso em jardim de infância, refletiu- -se sobre como e com quais ferramentas de apoio se pode avaliar e promover qualidade e intervenção educativa adequada nos contextos. Selecionou-se um grupo de crianças (entre 3 e 6 anos) e desenvolveram-se estratégias com a finalidade de escutar e compreender o modo como elas participam. Ainda, em diversos tempos da rotina de ca...
Bem-Estar Emocional e Implicação: estudo com crianças em Acolhimento Institucional
Andrade, Sofia; Santos, Paula; Costa, António Pedro; Neri de Souza, DayseThis research project focuses on the curricula developed in a day care and a kindergarten attended by children living in institutional care. Based on four case studies, this study aimed to analyze how children experience the curriculum, through the evaluation of process variables: Emotional Well-being (EWB) and Involvement (I). For each activity experienced by children involved in the study, we performed a...
Evaluation of the prevalence and caracterization of rinosinusitis in primary he...
Barros, Ezequiel; Silva, Agostinho; Vieira, António Sousa; André, Carla; Silva, Deodato; Prata, João Branquinho; Ferreira, João Pinto; Santos, MargaridaObjective: To determine RS prevalence, diagnosed at the Portuguese Primary Health Care Centres (PHCC), and to assess diagnostic and treatment practices.Study Design: Epidemiologic, cross-sectional study.Material and Methods: A cohort of subjects attending general practice medical appointments, in selected PHCC, was evaluated.Results: Between May/2008 and June/2009, 1,201 subjects were included with a mean age o...
Avaliação de dimensões contextuais em educação de infância
Andrade, Sofia; Santos, Paula CoelhoEste projeto de investigação focaliza-se nos currículos desenvolvidos numa creche e num jardim-de-infância que atendem crianças em situação de acolhimento institucional. O objetivo é analisar as dimensões contextuais presentes, nomeadamente ao nível da oferta educativa, clima de grupo, espaço para iniciativa, organização e estilo do adulto, por referência à perspetiva das crianças envolvidas no estudo. A partir...
Hepatitis C in drug addicts: access and treatment compliance.
Sarmento E Castro, Rui; Valente, Cristina; Ramos, José Presa; Almeida, José Rocha; Marinho, Rui Tato; Branco, Teresa; Andrade, Sofia; Macedo, AnaCurrently, hepatitis C is a serious public health problem. It is estimated that there are 180 million people with chronic infection by hepatitis C virus (HCV) worldwide and that the prevalence of this infection in the Portuguese population ranges between 1 and 1.5%. In Portugal, there are neither up-to-date guidelines for treatment, nor recommendations for the diagnosis and management of patients with HCV and, ...
Incremental cost evaluation study of INR self-monitoring versus laboratorial co...
Macedo, Ana; Carrasco, João; Andrade, Sofia; Moital, InêsOral anticoagulant therapy with vitamin K blockers has been increasing in the last few years and its effectiveness is directly related to maintaining INR values within the target range. The objective of this study is to evaluate the cost-effectiveness of INR auto-monitoring versus monitoring in a laboratory or a health care centre, in Portugal.The study was conducted from a social perspective and considered onl...
Cost-effectiveness of trastuzumab in the treatment of early stages breast cance...
Macedo, Ana; Monteiro, Isabel; Andrade, Sofia; Cirrincione, A; Ray, JDespite the important advances observed in the last 25 years in the comprehension of the clinical and biological nature of breast cancer and its treatment, this disease remains a significant cause of cancer morbidity and mortality worldwide. The clinical trial Hera has demonstrated the safety and efficacy of trastuzumab in the treatment of HER2 positive (HER2+) breast cancer patients, in early stages, subsequen...
Guidelines for prevention of febrile neutropenia.
Barroso, Sérgio; Damasceno, Margarida; Dinis, José; Gervásio, Helena; da Luz, Ricardo; Passos-Coelho, J L; Sá, Anabela; Costa, Luís; Rodrigues, HelenaNeutropenia and febrile neutropenia are common consequences of some cytotoxic chemotherapy regimens. This situation leads to modifications of the therapeutic regimen, conducting to either dose reduction or cycle delays. Granulocyte colony stimulating factors are commonly used to minimize chemotherapy cytotoxic effect on the granulocytic series. The objective of this study is to assess the available evidence in ...
Characterization of oncological disease: racional, objectives and methodology -...
Macedo, Ana; Andrade, Sofia; Moital, Inês; Moreira, António; Pimentel, Francisco Luís; Barroso, Sérgio; Dinis, José; Afonso, Noémia; Bonfill, XavierOncologic disease is one of the main causes of death in Portugal, as well as a high morbidity rate. Over the past few years, these diseases have been targeted with several strategies which aims at optimizing the use of available therapeutic and diagnostic options. Nevertheless, the amount of quantitative information available regarding the disease, patient profile, and treatment and monitoring practices is very...