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PLGA nanoparticles double-decorated with a TAT peptide and folic acid to target...

Andrade, Stéphanie; Ramalho, Maria J.; Santos, João; Santos, Sílvio Roberto Branco; Melo, Luís Daniel Rodrigues; Guimarães, Nuno; Ferraz, Maria P.

Treating bacterial infections has become increasingly difficult due to the rise in antibiotic-resistant bacterial strains. Strategies involving the targeted delivery of antibiotics have been proposed to minimize the administered antibiotic doses. This study aims to develop the first double-modified nanovehicle capable of increasing bacterial membranes permeability while specifically targeting Staphylococcus aur...


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