14 documents found, page 1 of 2

Stanozolol induces ventricular dysfunction by decreasing phospholamban phosphor...

Stanozolol is a steroid that causes lipid deposition in LDLr-/- mice, although the mechanism by which this dyslipidemia results in cardiac dysfunction is little understood. The aim of this study was to evaluate the effect of stanozolol on cardiac contractility and the participation of myocardial phospholamban (pPLB) phosphorylation in an atherosclerosis mouse model. LDL receptor knockout mice (LDLr-/-) were fed...

A educação de farmacêuticos como ferramenta para melhoria do uso de medicamento...

O estudo objetivou avaliar o nível de conhecimento dos farmacêuticos sobre o Protocolo Clínico e Diretrizes Terapêuticas (PCDT)/Dislipidemia, antes e após treinamento, para implantação de serviços clínicos em farmácia pública de dispensação de medicamentos especializados e a percepção de usuários dislipidêmicos atendidos nesta farmácia, sobre o uso, as reações adversas e medidas de promoção da saúde, antes e ap...

Chronic treatment with juçara (Euterpe edulis) fruit pulp produces antihyperten...

Background: Juçara açaí is a Brazilian berry with high anthocyanidin content and high antioxidant properties. A correlation between oxidative stress, hypertension and baroreflex impairment is known, however, no previous studies investigate the effect of juçara fruit pulp on hypertension. Aim: The aim of this study was to investigate antihypertensive effect of juçara (Euterpe edulis) fruit pulp in SHR animals, i...

Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis ...

Contrast-induced nephropathy (NIC) is directly related to increased morbidity and mortality, and its treatment and prevention might be achieved by the administration of antioxidant products. The juçara palmetto (Euterpe edulis Martius) has fruits rich in phenolic compounds, which are known for their antioxidant activity. This work aimed to evaluate the nephroprotective activity of E. edulis pulp in the NIC anim...

Finasteride promotes worsening of the cardiac deleterious effects of nandrolone...

Metabolism of anabolic androgenic steroids is important for its physiological effects. The aim was to investigate the effects of finasteride (a 5α-reductase inhibitor - 5αR) on cardiac and mutagenic effects promoted by ND. Male Wistar rats were separated into three groups: CONT, received the vehicles of ND and finasteride (Peanut oil+Saline); DECA group, received ND (20 mg.kg.week-1, i.m.), and DECAF received N...

Chronic administration of the soluble, nonbacterial fraction of kefir attenuate...

Level of satisfaction of clients of public pharmacies dispensing high-cost drug...

O objetivo do presente estudo foi avaliar o nível de satisfação dos serviços farmacêuticos e a determinação do perfil socioeconômico de clientes de farmácias públicas. Trata-se de um estudo observacional transversal com abordagem quantitativa. A amostra foi calculada através de dados da quantidade mensal de pacientes atendidos nas farmácias e estratificada para cada unidade do Estado. Os dados foram analisados ...

Hypotensive effect and endothelium-dependent vascular action of leaves of Alpin...

Os objetivos deste estudo foram avaliar o perfil químico de folhas de Alpinia purpurata K. Schum (AP), assim como a reatividade vascular e o efeito hipotensor agudo (EHA) do extrato etanólico de folhas de AP (EEAP). Avliou-se o perfil químico utilizando-se HPLC-UV, ICP-OES e quantificação colorimétrica de flavonoides e polifenóis totais. A reatividade vascular foi determinada utilizando leito mesentérico isolad...

Hepatitis C in prisoners and non-prisoners in Colatina, Espírito Santo, Brazil

The aim of the present work was to compare hepatitis C prevalence, genotypes, and risk factors between prisoners and non-prisoners in the city of Colatina, Espírito Santo, Brazil. This cross-sectional study involved approximately 1,600 residents and 730 prisoners, all of whom were living in Colatina. The percentage of individuals who tested positive for anti-HCV was 0.1% (2/1,600) in the non-prisoner group and ...

In vivo hypotensive effect and in vitro inhibitory activity of some Cyperaceae ...

In 1820, French naturalist August Saint Hillaire, during a visit in Espírito Santo (ES), a state in southeastern Brazil, reported a popular use of Cyperaceae species as antidote to snake bites. The plant may even have a hypotensive effect, though it was never properly researched. The in vitro inhibitory of the angiotensin converting enzyme (ACE) activity of eigth ethanolic extracts of Cyperaceae was evaluated b...