10 documents found, page 1 of 1
Proteômica quantitativa baseada em espectrometria de massas para estudo do trat...
Neves, Leandro XavierPrograma de Pós-Graduação em Biotecnologia. Núcleo de Pesquisas em Ciências Biológicas, Pró-Reitoria de Pesquisa de Pós Graduação, Universidade Federal de Ouro Preto.; A esquistossomose é uma doença tropical negligenciada que afeta mais de 240 milhões de pessoas em 78 países. Apesar dos esforços para erradicação da doença, fatores como baixa cobertura dos programas de tratamento quimioterápico, métodos diagnóst...
Differential expression of proteins in genetically distinct Trypanosoma cruzi s...
Oliveira, Maykon Tavares de; Rúbio, Karina Taciana Santos; Neves, Leandro Xavier; Toledo, Max Jean de Ornelas; Borges, William de Castro; Lana, Marta deBackground Trypanosoma cruzi, a hemoflagellate protozoan parasite and the etiological agent of Chagas disease (CD), exhibits great genetic and biological diversity. Infected individuals may present clinical manifestations with different levels of severity. Several hypotheses have been proposed to attempt to correlate the diversity of clinical signs and symptoms to the genetic variability of T. cruzi. This work ...
Cromatografia de afinidade pelo ácido ε-aminocapróico para purificação e depleç...
Neves, Leandro XavierPrograma de Pós-Graduação em Biotecnologia. Núcleo de Pesquisas em Ciências Biológicas, Pró-Reitoria de Pesquisa de Pós Graduação, Universidade Federal de Ouro Preto.; Imunoglobulinas ou anticorpos são glicoproteínas produzidas pelas células B. Estas moléculas podem ser encontradas ancoradas na membrana plasmática da célula produtora ou em fluidos corporais, como sangue e líquido ascítico, na sua forma secretad...
Microexon gene transcriptional profiles and evolution provide insights into blo...
Li, Xiao Hong; DeMarco, Ricardo; Neves, Leandro Xavier; James, Sally R.; Newling, Katherine; Ashton, Peter D.; Cao, Jian Ping; Wilson, R. AlanAdult schistosomes have a well-developed alimentary tract comprising an oral sucker around the mouth, a short esophagus and a blind ending gut. The esophagus is not simply a muscular tube for conducting blood from the mouth to gut but is divided into compartments, surrounded by anterior and posterior glands, where processing of ingested blood is initiated. Self-cure of rhesus macaques from a Schistosoma japonic...
Exposure of cultured fibroblasts to the peptide PR-11 for the identification of...
Breguez, Gustavo Silveira; Neves, Leandro Xavier; Rúbio, Karina Taciana Santos; Freitas, Lorran Miranda Andrade de; Faria, Gabriela de OliveiraThe PR-11 peptide corresponds to the N-terminal and active region of the endogenously synthesized PR-39 molecule, of porcine origin. It is known to possess various biological effects including antimicrobial properties, angiogenic and anti-inflammatory activities. Apart from its reported activity as a proteasome inhibitor, a more comprehensive understanding of its function, at the molecular level, is still lacki...
Understanding global changes of the liver proteome during murine schistosomiasi...
Campos, Jonatan Marques; Neves, Leandro Xavier; Paiva, Nívia Carolina Nogueira de; Castro, Renata Alves de Oliveira e; Casé, Ana HelenaSchistosomiasis is an endemic disease affecting over 207million people worldwide caused by helminth parasites of the genus Schistosoma. In Brazil the disease is responsible for the loss of up to 800 lives annually, resulting from the desabilitating effects of this chronic condition. In this study, we infected Balb/c mice with Schistosoma mansoni and analysed global changes in the proteomic profile of soluble li...
What’s in SWAP? Abundance of the principal constituents in a soluble extract of...
Neves, Leandro Xavier; Sanson, Ananda Lima; Wilson, R. Alan; Borges, William de CastroBackground: The soluble antigen preparation of adult schistosomes (SWAP) has often been used to probe host responses against these blood-dwelling parasites. Despite its long established use there is limited knowledge about its composition. The information we provide here on the molecular composition of SWAP may contribute as a guide for a rational selection of antigenic targets. Methods: Label-free quantitative...
Whey protein improves HDL/non-HDL ratio and body weight gain in rats subjected ...
Teixeira, Kely Raspante; Silva, Marcelo Eustáquio; Neves, Leandro Xavier; Santos, Rinaldo Cardoso dos; Pedrosa, Maria Lúcia; Haraguchi, Fabiano KenjiThe aim of this study was to evaluate the effects of resistance exercise, such as weight-lifting (WL) on the biochemical parameters of lipid metabolism and cardiovascular disease risk in the rats fed casein (control) or whey protein (WP) diets. Thirty-two male Fisher rats were randomly assigned to sedentary or exercise-trained groups and were fed control or WP diets. The WL program consisted of inducing the ani...
The schistosome eesophageal gland : initiator of blood processing.
Li, Xiao Hong; Borges, William de Castro; Manuel, Sophie J. Parker; Vance, Gillian M.; DeMarco, Ricardo; Neves, Leandro Xavier; Evans, Garet J. O.Background: Although the ultrastructure of the schistosome esophageal gland was described .35 years ago, its role in the processing of ingested blood has never been established. The current study was prompted by our identification of MEG-4.1 expression in the gland and the observation of erythrocyte uncoating in the posterior esophagus. Methodology/Principal Findings: The salient feature of the posterior esopha...
Whey protein modifies gene expression related to protein metabolism affecting m...
Haraguchi, Fabiano Kenji; Magalhães, Cíntia Lopes de Brito; Neves, Leandro Xavier; Santos, Rinaldo Cardoso dos; Pedrosa, Maria LúciaObjective: The aim of this study was to evaluate the effects of resistance exercise on the mRNA expression of muscle mammalian target of rapamycin (mTOR), muscle-specific RING finger-1 (MuRF-1), and muscle atrophy F-box (MAFbx) in the presence or absence of whey protein ingestion. We hypothesized that resistance exercise in combination with whey protein ingestion alters the gene expression of proteins related t...