7 documents found, page 1 of 1
Strong SOD2 expression and HPV-16/18 positivity are independent events in cervi...
Rabelo-Santos, Silvia Helena; Termini, Lara; Boccardo, Enrique; Derchain, Sophie; Longatto, Adhemar; Andreoli, Maria Antonieta; Costa, Maria CecíliaIt is well known that persistent infection with high-risk HPV (hr-HPV), mostly HPV-16 and 18, is the main cause of cervical cancer development. Manganese superoxide dismutase (MnSOD or SOD2) are highly expressed in different neoplasia. The present study investigated SOD2 protein expression and the presence of hr-HPV types in 297 cervical samples including non-neoplastic tissue, cervical intraepithelial neoplasi...
Local and systemic immunomodulatory mechanisms triggered by Human Papillomaviru...
Alvarez, Karla Lucia Fernandez; Beldi, Mariana Carmezim; Sarmanho, Fabiane; Rossetti, Renata Ariza Marques; Silveira, Caio Raony FarinaCervical cancer is the last stage of a series of molecular and cellular alterations initiated with Human Papillomavirus (HPV) infection. The process involves immune responses and evasion mechanisms, which culminates with tolerance toward tumor antigens. Our objective was to understand local and systemic changes in the interactions between HPV associated cervical lesions and the immune system as lesions progress...
SOD2 immunoexpression predicts lymph node metastasis in penile cancer
Termini, Lara; Fregnani, José Humberto; Boccardo, Enrique; Costa, Walter H. da; Longatto Filho, Adhemar; Andreoli, Maria Antonieta; Costa, Maria CeciliaBACKGROUND: Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme in lung, gastric, colorectal, breast cancer and cervical cancer malignant tumors has been observed. Its relationship with inguinal lymph node metastasis in penile cancer is unknown. METHODS: SOD2 protein expression...
HPV16 oncoproteins induce MMPs/RECK-TIMP-2 imbalance in primary keratinocytes :...
Cardeal, Laura Beatriz da Silva; Boccardo, Enrique; Termini, Lara; Rabachini, Tatiana; Andreoli, Maria Antonieta; Loreto, Celso di; Filho, A. L.Cervical cancer is the third most common cancer in women worldwide. Persistent infection with high-risk HPV types, principally HPV16 and 18 is the main risk factor for the development of this malignancy. However, the onset of invasive tumor occurs many years after initial exposure in a minority of infected women. This suggests that other factors beyond viral infection are necessary for tumor establishment and p...
Seroprevalence of human papillomavirus 6, 11, 16, and 18 in young primiparous w...
Rama, Cristina Helena; Villa, Luisa Lina; Paglius, Sonia; Andreoli, Maria Antonieta; Costa, Maria Cecilia; Thomann, PatriciaINTRODUCTION: Data on epidemiology of HPV infection are needed for the development of human papillomavirus (HPV) vaccine recommendations, especially in countries where HPV vaccination is not yet included in public vaccination programs. The aim of this study was to determine the prevalence of serum antibodies to HPV types 6, 11, 16, and 18 and associated factors among young women after birth of the first child. ...
Awareness and knowledge of HPV, cervical cancer, and vaccines in young women af...
Rama, Cristina Helena; Villa, Luisa Lina; Paglius, Sonia; Andreoli, Maria Antonieta; Costa, Maria Cecilia; Aoki, Aline L.; Longatto Filho, AdhemarBACKGROUND: The success of HPV vaccination programs will require awareness regarding HPV associated diseases and the benefits of HPV vaccination for the general population. The aim of this study was to assess the level of awareness and knowledge of human papillomavirus (HPV) infection, cervical cancer prevention, vaccines, and factors associated with HPV awareness among young women after birth of the first chil...
Opportunity for catch-up HPV vaccination in young women after first delivery
Rama, Cristina Helena; Villa, Luisa Lina; Paglius, Sonia; Andreoli, Maria Antonieta; Costa, Maria Cecilia; Thomann, PatriciaBACKGROUND: Early age at first delivery has been identified as a risk factor for high-risk HPV-type infection and cervical cancer development. METHODS: A cross-sectional study was carried out in a large public maternity hospital in São Paulo, Brazil. During June 2006 to February 2007, 301 women aged 15-24 years who gave birth to their first child were recruited between 43 and 60 days after delivery. Detection o...