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Coupling the antimalarial cell penetrating peptide TP10 to classical antimalari...

Aguiar, Luísa; Biosca, Arnau; Lantero, Elena; Gut, Jiri; Vale, Nuno; Rosenthal, Philip J.; Nogueira, Fátima; Andreu, David; Fernàndez-Busquets, Xavier

Recently, we disclosed primaquine cell penetrating peptide conjugates that were more potent than parent primaquine against liver stage Plasmodium parasites and non-toxic to hepatocytes. The same strategy was now applied to the blood-stage antimalarial chloroquine, using a wide set of peptides, including TP10, a cell penetrating peptide with intrinsic antiplasmodial activity. Chloroquine-TP10 conjugates displayi...

Date: 2019   |   Origin: Repositório Institucional da UNL
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