2 documents found, page 1 of 1
Cephalopods in neuroscience: regulations, research and the 3Rs
Fiorito, Graziano; Affuso, Andrea; Anderson, David B; Basil, Jennifer; Bonnaud, Laure; Botta, Giovanni; Cole, Alison; D'Angelo, LiviaCephalopods have been utilised in neuroscience research for more than 100 years particularly because of their phenotypic plasticity, complex and centralised nervous system, tractability for studies of learning and cellular mechanisms of memory (e.g. long-term potentiation) and anatomical features facilitating physiological studies (e.g. squid giant axon and synapse). On 1 January 2013, research using any of the...
Differential RET signaling pathways drive development of the enteric lymphoid a...
Patel, Amisha; Harker, Nicola; Moreira-Santos, Lara; Ferreira, Manuela; Alden, Kieran; Timmis, Jon; Foster, Katie; Garefalaki, Anna; Pachnis, PanayotisDuring the early development of the gastrointestinal tract, signaling through the receptor tyrosine kinase RET is required for initiation of lymphoid organ (Peyer’s patch) formation and for intestinal innervation by enteric neurons. RET signaling occurs through glial cell line–derived neurotrophic factor (GDNF) family receptor α co-receptors present in the same cell (signaling in cis). It is unclear whether RET...