12 documents found, page 1 of 2
Planejamento de fármacos, biotecnologia e química medicinal: Aplicações em doen...
Guido, Rafael V.C. [UNESP]; Andricopulo, Adriano D.; Oliva, GlauciusMade available in DSpace on 2022-04-28T18:56:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-12-21; Current drug design strategies are based on the understanding of the physiopathology of diseases, biochemical pathways and selection of molecular targets. Modern biotechnological tools have provided valuable information to facilitate the discovery of new drug candidates. Medicinal chemistry has a vital ...
Identification of a Prenyl Chalcone as a Competitive Lipoxygenase Inhibitor: Sc...
Zeraik, Maria Luiza [UNESP]; Pauli, Ivani; Dutra, Luiz A. [UNESP]; Cruz, Raquel S. [UNESP]; Valli, Marilia [UNESP]; Paracatu, Luana C. [UNESP]Made available in DSpace on 2021-06-25T10:59:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-12; Fundação Araucária; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Cyclooxygenase (COX) and lipoxygenase (LOX) are key targets for the development of new anti-inflammatory agents. LOX, which is involved in the biosynth...
Linear peptide analogues from Jatropha's orbitides promote migration of human n...
Ramalho, Suelem D. [UNESP]; Pinto, Meri Emili F. [UNESP]; Andricopulo, Renata K.; Sanches, Paulo R. S. [UNESP]; Silveira, Edilberto R.Made available in DSpace on 2020-12-12T02:32:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01. Added 1 bitstream(s) on 2021-07-15T15:07:38Z : No. of bitstreams: 1 S0103-50532019001002153.pdf: 2794919 bytes, checksum: cd2b9335294d2b610a9abbd5dc742734 (MD5); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Orbitides are a class of small naturally occurring cyclic peptides with structu...
Advanced Glycation End Product Inhibition by Alkaloids from Ocotea paranapiacab...
Freitas, Larissa De [UNESP]; Valli, Marilia [UNESP]; Dametto, Alessandra C. [UNESP]; Pennacchi, Paula C.; Andricopulo, Adriano D.Made available in DSpace on 2020-12-12T01:59:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; A bioassay-guided study aiming at identifying inhibitors of the glycation process on the leaves of Ocotea paranapiacabensis afforded four benzylisoquinoline alkaloids (1-4), with 1 and 2 identified as new naturals products, while 3 and 4 were previously described in the literature, with 3 being identifi...
Effect of cis-9, trans-11 conjugated linoleic acid (CLA) on the metabolism prof...
Maria, Roberta M.; Altei, Wanessa F.; Valadares, Napoleão Fonseca; Garratt, Richard C.; Andricopulo, Adriano D.; Venâncio, Tiago; Colnago, Luiz A.Conjugated linoleic acid (CLA), a fatty acid found in ruminant food products, has been associated with anticarcinogenic activity. However, its effect on cancer metabolism is unclear. In this paper we evaluated the effects of cis-9, trans-11 CLA on the metabolic profile of MCF-7 and MDA-MB-231 breast cancer cells using high-resolution magic angle spinning (HR-MAS) nuclear magnetic resonance (NMR) spectroscopy. T...
NuBBEDB: An updated database to uncover chemical and biological information fro...
Pilon, Alan C. [UNESP]; Valli, Marilia [UNESP]; Dametto, Alessandra C. [UNESP]; Pinto, Meri Emili F. [UNESP]; Freire, Rafael T.Made available in DSpace on 2018-12-11T17:13:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-12-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); The intrinsic value of biodiversity extends beyond species diversity, genetic heritage, ecosystem variability and ecological services, such as climate regulation, water qua...
Synthetic analogue of the natural product piperlongumine as a potent inhibitor ...
Valli, Marilia [UNESP]; Altei, Wanessa; Dos Santos, Ricardo N.; De Lucca, Emilio C.; Dessoy, Marco A.; Pioli, Renan M. [UNESP]; Cotinguiba, FernandoMade available in DSpace on 2018-12-11T17:31:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-03-01. Added 1 bitstream(s) on 2019-10-09T18:32:48Z : No. of bitstreams: 1 S0103-50532017000300475.pdf: 612042 bytes, checksum: 72fdf2c23c51d9f3984b194b81219854 (MD5); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fund...
Classical and hologram QSAR studies on a series of inhibitors of trypanosomatid...
Guido, Rafael V. C.; Castilho, Marcelo Santos; Mota, Sabrina G. R.; Oliva, Glaucius; Andricopulo, Adriano D.; Guido, Rafael V. C.Texto completo: acesso restrito. p. 768-781; Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-12-05T15:11:05Z No. of bitstreams: 1 10.1002qsar.200710139.pdf: 343846 bytes, checksum: d0ad2b669216428580985a3321346ce3 (MD5); Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-01-21T20:58:20Z (GMT) No. of bitstreams: 1 10.1002qsar.200710139.pdf: 343846 bytes, checksum: d0ad2b6692...
2D Quantitative structure–activity relationship studies on a series of choleste...
Castilho, Marcelo Santos; Guido, Rafael V. C.; Andricopulo, Adriano D.; Castilho, Marcelo Santos; Guido, Rafael V. C.; Andricopulo, Adriano D.Texto completo: acesso restrito. p. 6242-6252; Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-01-14T17:06:46Z No. of bitstreams: 1 1-s2.0-S0968089607005445-main.pdf: 463973 bytes, checksum: a753790176d7a99f075fe5669cc452c4 (MD5); Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-01-21T20:58:37Z (GMT) No. of bitstreams: 1 1-s2.0-S0968089607005445-main.pdf: 463973 bytes, ch...
Structural basis for selective inhibition of purine nucleoside phosphorylase fr...
Castilho, Marcelo Santos; Postigo, Matheus P.; Pereira, Humberto M.; Oliva, Glaucius; Andricopulo, Adriano D.; Castilho, Marcelo SantosTrabalho completo: acesso restrito, p. 1421–1427; Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-05-29T16:52:18Z No. of bitstreams: 1 (39)1-s2.0-S096808961000043X-main.pdf: 998932 bytes, checksum: 90bd5773640cb0d48d8c9ddf633bc2d8 (MD5); Made available in DSpace on 2012-05-29T16:52:18Z (GMT). No. of bitstreams: 1 (39)1-s2.0-S096808961000043X-main.pdf: 998932 bytes, checksum: 90bd5773640cb0d48d8c9ddf633bc...