30 documents found, page 1 of 3
Glial-restricted precursors stimulate endogenous cytogenesis and effectively re...
Martins-Macedo, Joana; Araújo, Bruna; Anjo, Sandra I.; Silveira-Rosa, Tiago; Patrício, Patrícia; Alves, Nuno Dinis; Silva, Joana M.; Teixeira, Fábio G.Adult cytogenesis, the continuous generation of newly-born neurons (neurogenesis) and glial cells (gliogenesis) throughout life, is highly impaired in several neuropsychiatric disorders, such as Major Depressive Disorder (MDD), impacting negatively on cognitive and emotional domains. Despite playing a critical role in brain homeostasis, the importance of gliogenesis has been overlooked, both in healthy and dise...
Metabolic Priming as a Tool in Redox and Mitochondrial Theragnostics
Pinho, Sónia A.; Anjo, Sandra I.; Cunha-Oliveira, TeresaTheragnostics is a promising approach that integrates diagnostics and therapeutics into a single personalized strategy. To conduct effective theragnostic studies, it is essential to create an in vitro environment that accurately reflects the in vivo conditions. In this review, we discuss the importance of redox homeostasis and mitochondrial function in the context of personalized theragnostic approaches. Cells ...
Chronic treatment with D2-antagonist haloperidol leads to inhibitory/excitatory...
Santa, Cátia; Rodrigues, Diana; Coelho, Joana F.; Anjo, Sandra I.; Mendes, Vera M.; Bessa-Neto, Diogo; Dunn, Michael J.; Cotter, David; Baltazar, GraçaStriatal dysfunction has been implicated in the pathophysiology of schizophrenia, a disorder characterized by positive symptoms such as hallucinations and delusions. Haloperidol is a typical antipsychotic medication used in the treatment of schizophrenia that is known to antagonize dopamine D2 receptors, which are abundantly expressed in the striatum. However, haloperidol's delayed therapeutic effect also sugge...
New Insights on Sperm Function in Male Infertility of Unknown Origin: A Multimo...
Pacheco, Rita I.; Cristo, Maria I.; Anjo, Sandra I.; Silva, Andreia F.; Sousa, Maria Inês; Santos Tavares, Renata; Sousa, Ana PaulaThe global trend of rising (male) infertility is concerning, and the unidentifiable causes in half of the cases, the so-called unknown origin male infertility (UOMI), demands a better understanding and assessment of both external/internal factors and mechanisms potentially involved. In this work, it was our aim to obtain new insight on UOMI, specifically on idiopathic (ID) and Unexplained male infertility (UMI)...
Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer
Coelho, Margarida; Capela, João; Anjo, Sandra I.; Pacheco, João; Fernandes, Margarida Sá; Amendoeira, Isabel; Jones, John G.; Raposo, LuísDifferentiated thyroid cancer is the most common malignancy of the endocrine system. Although most thyroid nodules are benign, given the high incidence of thyroid nodules in the population, it is important to understand the differences between benign and malignant thyroid cancer and the molecular alterations associated with malignancy to improve detection and signal potential diagnostic, prognostic, and therape...
Mass Spectrometry-Based Proteomic and Metabolomic Profiling of Serum Samples fo...
Fernandes, Ana Filipa; Gonçalves, Luís Gafeira; Bento, Maria; Anjo, Sandra I.; Manadas, Bruno; Barroso, Clara; Villar, Miguel; Macedo, RitaTuberculosis (TB) is a transmissible disease listed as one of the 10 leading causes of death worldwide (10 million infected in 2019). A swift and precise diagnosis is essential to forestall its transmission, for which the discovery of effective diagnostic biomarkers is crucial. In this study, we aimed to discover molecular biomarkers for the early diagnosis of tuberculosis. Two independent cohorts comprising 29...
Endogenous Fluorescent Proteins in the Mucus of an Intertidal Polychaeta: Clues...
Rodrigo, Ana P.; Lopes, Ana; Pereira, Ricardo; Anjo, Sandra I.; Manadas, Bruno; Grosso, Ana R.; Baptista, Pedro V.; Fernandes, Alexandra R.The vast ocean holds many unexplored organisms with unique adaptive features that enable them to thrive in their environment. The secretion of fluorescent proteins is one of them, with reports on the presence of such compounds in marine annelids being scarce. The intertidal Eulalia sp. is an example. The worm secretes copious amounts of mucus, that when purified and concentrated extracts, yield strong fluoresce...
Modulation of signaling pathways by DJ-1: An updated overview
Neves, Margarida; Grãos, Mário; Anjo, Sandra I.; Manadas, BrunoEfforts have been made to understand the physiological and pathological role of DJ-1, a Parkinson's disease (PD)-associated protein, to provide new insights into PD pathophysiology. Such studies have revealed several neuroprotective roles of DJ-1, from which its ability to modulate signaling pathways seems to be of utmost importance for cell death regulation by DJ-1. Indeed, research on these topics has led to ...
Virulence Biomarkers of Bursaphelenchus xylophilus: A Proteomic Approach
Cardoso, Joana M. S.; Anjo, Sandra I.; Manadas, Bruno; Silva, Hugo; Abrantes, Isabel M. O.; Nakamura, Katsunori; Fonseca, LuísThe pinewood nematode (PWN), Bursaphelenchus xylophilus, one of the most serious forest pests worldwide, is considered the causal agent of the pine wilt disease (PWD). The main host species belong to the genus Pinus, and a variation in the susceptibility of several pine species to PWN infection is well-known. It is also recognized that there is variation in the virulence among B. xylophilus isolates. In the pre...
Comparative Analysis of Bursaphelenchus xylophilus Secretome Under Pinus pinast...
Silva, Hugo; Anjo, Sandra I.; Manadas, Bruno; Abrantes, Isabel; Fonseca, Luís; Cardoso, Joana M. S.The pinewood nematode (PWN), Bursaphelenchus xylophilus, the pine wilt disease's (PWD) causal agent, is a migratory endoparasitic nematode skilled to feed on pine tissues and on fungi that colonize the trees. In order to study B. xylophilus secretomes under the stimulus of pine species with different susceptibilities to disease, nematodes were exposed to aqueous pine extracts from Pinus pinaster (high-susceptib...