3 documents found, page 1 of 1
Cofilin-1 is a mechanosensitive regulator of transcription
Domingues, Catarina; Geraldo, A Margarida; Anjo, Sandra Isabel; Matos, André; Almeida, Cláudio; Caramelo, Inês; Lopes-da-Silva, José A; Paiva, ArturThe mechanical properties of the extracellular environment are interrogated by cells and integrated through mechanotransduction. Many cellular processes depend on actomyosin-dependent contractility, which is influenced by the microenvironment's stiffness. Here, we explored the influence of substrate stiffness on the proteome of proliferating undifferentiated human umbilical cord-matrix mesenchymal stem/stromal ...
Do hypoxia/normoxia culturing conditions change the neuroregulatory profile of ...
Teixeira, Fábio G; Panchalingam, Krishna M; Anjo, Sandra Isabel; Manadas, Bruno; Pereira, Ricardo; Sousa, Nuno; Salgado, António J.; Behie, Leo AIntroduction: The use of human umbilical cord Wharton Jelly-derived mesenchymal stem cells (hWJ-MSCs) has been considered a new potential source for future safe applications in regenerative medicine. Indeed, the application of hWJ-MSCs into different animal models of disease, including those from the central nervous system, has shown remarkable therapeutic benefits mostly associated with their secretome. Conven...
Do hypoxia/normoxia culturing conditions change the neuroregulatory profile of ...
Teixeira, Fábio Gabriel Rodrigues; Panchalingam, Krishna M.; Anjo, Sandra Isabel; Manadas, Bruno; Pereira, Ricardo Nuno Correia; Sousa, NunoIntroduction: The use of human umbilical cord Wharton Jelly-derived mesenchymal stem cells (hWJ-MSCs) has been considered a new potential source for future safe applications in regenerative medicine. Indeed, the application of hWJ-MSCs into different animal models of disease, including those from the central nervous system, has shown remarkable therapeutic benefits mostly associated with their secretome. Conven...