5 documents found, page 1 of 1
Response properties of nociceptive neurons in the caudal ventrolateral medulla ...
Ribeiro, Filipa Pinto; Ansah, Osei B.; Almeida, Armando; Pertovaara, AnttiWe characterized response properties of neurons in the caudal ventrolateral medulla (CVLM), a structure involved in pain modulation. Electrophysiological recordings were performed in pentobarbitoneanesthetized control and monoarthritic rats. Noxious pinch, heat, cold and colorectal distension were used for peripheral test stimulation. To study central modulation of CVLM neurons and role in mediating descending ...
Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-r...
Ansah, Osei B.; Bourbia, Nora; Gonçalves, Leonor; Almeida, Armando; Pertovaara, AnttiThe role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous acti...
Enhanced pronociception by amygdaloid group I metabotropic glutamate receptors ...
Ansah, Osei B.; Gonçalves, Leonor; Almeida, Armando; Pertovaara, AnttiPeripheral neuropathy has been associated with structural and functional changes of the amygdala, a key player in emotions. Here we study whether peripheral neuropathy influences pain regulation by the amygdala. For this purpose, we determined discharge rates of presumably pro- and antinociceptive pain-regulatory neurons in the rostral ventromedial medulla (RVM) following microinjection of various glutamatergic...
Influence of arthritis on descending modulation of nociception from the paraven...
Ribeiro, Filipa Pinto; Ansah, Osei B.; Almeida, Armando; Pertovaara, AnttiWe studied the influence of arthritis on descending modulation of nociception from the hypothalamic paraventricular nucleus (PVN) in the rat. Spinal nociception was assessed by the heat-evoked limb withdrawal in awake animals while neuronal responses were recorded in a potential brainstem relay, the rostroventromedial medulla (RVM), under pentobarbitone anesthesia. Following injection into the PVN, glutamate at...
Striatal dopamine D-2 receptors attenuate neuropathic hypersensitivity in the rat
Ansah, Osei B.; Leite-Almeida, Hugo; Wei, Hong; Pertovaara, AnttiEarlier studies indicate that striatal dopamine D-2 receptors are involved in pain regulation in non-neuropathic conditions. We assessed whether striatal dopamine D-2 receptors contribute to pain regulation also in neuropathic conditions. The spared nerve injury model of neuropathy was induced by unilateral ligation of the tibial and common peroneal nerves in the rat. In awake nerve-injured animals, pain-relate...