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Unravelling cell type-specific responses to Parkinson's Disease at single cell ...
Martirosyan, A; Ansari, R; Pestana, F; Hebestreit, K; Gasparyan, H; Aleksanyan, R; Hnatova, S; Poovathingal, S; Marneffe, C; Thal, DR; Kottick, AParkinson’s Disease (PD) is the second most common neurodegenerative disorder. The pathological hallmark of PD is loss of dopaminergic neurons and the presence of aggregated α-synuclein, primarily in the substantia nigra pars compacta (SNpc) of the midbrain. However, the molecular mechanisms that underlie the pathology in different cell types is not currently understood. Here, we present a single nucleus transc...
Date: 2024
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Origin: Repositório Aberto da Universidade do Porto