2 documents found, page 1 of 1
Addressing the challenge of oligomerization in computational protein design
Silva, Diogo; Moreira, Pedro; Teixeira, Rita I.; Fernandes, Bárbara; Parada, Mariana; Vicente, João B.; Lousa, Diana; Soares, Cláudio M.Computational protein design is a field of research with potential to greatly impact areas such as drug development or enzyme technology, by combining knowledge-based and physics-based methods to design tailor-made proteins. This concept was introduced by David Baker with the development of Rosetta Commons. This is an extensive framework containing tools that enable protein design using physics-based scoring fu...
Computationally-designed miniproteins showing neutralization activity against S...
Moreira, Pedro Daniel Martins; Parada, Mariana; Fernandes, Bárbara; Buga, Carolina C.; Teixeira, Rita I.; Oliveira, Christine; Buckley, Stephen MichaelAs the COVID-19 pandemic demonstrated, the need for robust antiviral therapies against SARS-CoV-2 remains substantial. A promising strategy to meet this demand is through the development of proteins tailored for enhanced binding affinity to crucial viral targets, such as epitopes located on their fusion proteins. Among these targets is the Spike proteins receptor binding domain (RBD), which interacts with the h...