2 documents found, page 1 of 1
Predation stress causes excessive aggression in female mice with partial geneti...
Svirin, Evgeniy; Veniaminova, Ekaterina; Nunes, João; Gorlova, Anna; Umriukhin, Aleksei; Kalueff, Allan V.; Proshin, Andrey; Anthony, Daniel C.The interaction between brain serotonin (5-HT) deficiency and environmental adversity may predispose females to excessive aggression. Specifically, complete inactivation of the gene encoding tryptophan hydroxylase-2 (Tph2) results in the absence of neuronal 5-HT synthesis and excessive aggressiveness in both male and female null mutant (Tph2-/-) mice. In heterozygous male mice (Tph2+/-), there is a moderate red...
What Do Microglia Really Do in Healthy Adult Brain?
Augusto-Oliveira, Marcus; Arrifano, Gabriela P.; Lopes-Araújo, Amanda; Santos-Sacramento, Leticia; Takeda, Priscila Y.; Anthony, Daniel C.Microglia originate from yolk sac-primitive macrophages and auto-proliferate into adulthood without replacement by bone marrow-derived circulating cells. In inflammation, stroke, aging, or infection, microglia have been shown to contribute to brain pathology in both deleterious and beneficial ways, which have been studied extensively. However, less is known about their role in the healthy adult brain. Astrocyte...