2 documents found, page 1 of 1
Physiological and pathophysiological roles of the KCNK3 potassium channel in th...
Willer, ASM; Santos Gomes, J; Adao, R; Brás-Silva C; Eyries, M; Perez Vizcaino, F; Capuano, V; Montani, D; Antigny, FPotassium channel subfamily K member 3 (KCNK3), encoded by the KCNK3 gene, is part of the two-pore domain potassium channel family, constitutively active at resting membrane potentials in excitable cells, including smooth muscle and cardiac cells. Several physiological and pharmacological mediators, such as intracellular signalling pathways, extracellular pH, hypoxia and anaesthetics, regulate KCNK3 channel fun...
Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Ar...
Hautefort, A; Mendes Ferreira, P; Sabourin, J; Manaud, G; Bertero, T; Rucker Martin, C; Riou, M; Adao, R; Manoury, B; Lambert, M; Boet, A; Lecerf, FBACKGROUND: Monoallelic mutations in the gene encoding bone morphogenetic protein receptor 2 (Bmpr2) are the main genetic risk factor for heritable pulmonary arterial hypertension (PAH) with incomplete penetrance. Several Bmpr2 transgenic mice have been reported to develop mild spontaneous PAH. In this study, we examined whether rats with the Bmpr2 mutation were susceptible to developing more severe PAH. METHOD...