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Detection of sputum cofilin-1 as indicator of malignancy

Rangel, M. P.; Antonangelo, L.; Acencio, M. M. P.; Faria, C. S.; de Sá, V. K.; Leão, P. S.; Farhat, C.; Fabro, A T; Longatto, Adhemar; Reis, R. M.

Cofilin-1 (CFL1), a small protein of 18 kDa, has been studied as a biomarker due to its involvement in tumor cell migration and invasion. Our aim was to evaluate CFL1 as an indicator of malignancy and aggressiveness in sputum samples. CFL1 was analyzed by ELISA immunoassay in the sputum of 73 lung cancer patients, 13 cancer-free patients, and 6 healthy volunteers. Statistical analyses included ANOVA, ROC curves...

Date: 2018 | Origin: RepositóriUM - Universidade do Minho

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