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Methylation of the hsa-miR-124, SOX1, TERT, and LMX1A genes as biomarkers for p...

Rogeri, Caroline Domingues; Silveira, Henrique César Santejo; Causin, Rhafaela Lima; Villa, Luisa Lina; Stein, Maíra Degiovani

The methylation profile of genes in precursor lesions in cervical cancer was characterized to improve screening techniques for high-grade intraepithelial neoplasia.


The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High...

Kuil, Larissa de Melo; Lorenzi, Adriana Tarla; Stein, Maíra Degiovani; Resende, Júlio César Possati; Antoniazzi, Márcio; Longatto Filho, Adhemar

Objective: To compare the results of cervical cytology and high-risk HPV tests using samples obtained using two different collection modalities in a population of Brazilian women: self-collection (vaginal lavage) and cervical Pap testing. Methods: We enrolled 204 women who were aged 18-64 years and had previously obtained abnormal cervical cytology test results; 83.8% of them agreed to participate. The sample w...


A low-cost HPV immunochromatographic assay to detect high-grade cervical intrae...

Mariano, Vânia Sammartino; Lorenzi, Adriana Tarlá; Scapulatempo-Neto, Cristovam; Stein, Maíra Degiovani; Resende, Julio Cesar Possati

Objective To evaluate the reproducibility and accuracy of the HPV16/18-E6 test. Methods The study population was comprised of 448 women with a previously abnormal Pap who were referred to the Barretos Cancer Hospital (Brazil) for diagnosis and treatment. Two cervical samples were collected immediately before colposcopy, one for the hr-HPV-DNA test and cytology and the other for the HPV16/18-E6 test using high-a...


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