4 documents found, page 1 of 1
Brazilian red propolis: extracts production, physicochemical characterization, ...
de Carvalho, Felipe Mendes de Andrade; Schneider, Jaderson Kleveston; de Jesus, Carla Viviane Freitas; de Andrade, Luciana NaloneBrazilian red propolis has been proposed as a new source of compounds with cytotoxic activity. Red propolis is a resinous material of vegetal origin, synthesized from the bees of the Appis mellifera family, with recognized biological properties. To obtain actives of low polarity and high cytotoxic profile from red propolis, in this work, we proposed a new solvent accelerated extraction method. A complete 23 fac...
Praziquantel-loaded solid lipid nanoparticles: Production, physicochemical char...
Andrade, Luciana Nalone; Marques, Conrado; Barbosa, Thallysson; Santos, Rafael; Chaud, Marco Vinícius; Ferreira da Silva, ClassiusPraziquantel (PZQ) is an anthelmintic drug, being the first choice for the treatment of schistosomiasis. Its high hydrophobic character and its low water solubility are the main limitations to the development of liquid formulations for the oral administration of the drug. The aim of this work was to develop Solid Lipid Nanoparticles (SLN) for the loading of PZQ for the treatment of S. mansoni infections. PZQ-SL...
Avaliação da atividade antitumoral do óleo essencial da Mentha x villosa (Lamic...
Amaral, Ricardo GuimarãesCancer is the given name for a group of more than 100 diseases account for 13% of deaths worldwide and 15.1% in Brazil, with estimates of increased mortality. These data show the deficiency of more effective anticancer agents, leading to increased life expectancy or cure. In this context, nature is an alternative to the problem, for harboring a huge biodiversity and Brazil stands out for having the highest dive...
Evaluation of the cytotoxicity of structurally correlated p-menthane derivatives
Andrade, Luciana Nalone; Lima, Tamires Cardoso; Amaral, Ricardo Guimarães; Pessoa, Cláudia do Ó; Moraes Filho, Manoel Odorico de; Soares, Bruno MarquesCompounds isolated from essential oils play an important role in the prevention and treatment of cancer. Monoterpenes are natural products, and the principal constituents of many essential oils. The aim of this study was to investigate the cytotoxic potential of p-menthane derivatives. Additionally, analogues of perillyl alcohol, a monoterpene with known anticancer activity, were evaluated to identify the molec...