3 documents found, page 1 of 1
Comparative proteomic analysis of Rhipicephalus sanguineus sensu lato (Acari: I...
Sanches, Gustavo Seron; Villar, Margarita; Couto, Joana; Ferrolho, J.; Fernández de Mera, Isabel G.; André, Marcos RogérioThe tick vector Rhipicephalus sanguineus is established as a complex of closely related species with high veterinary-medical significance, in which the presence of different genetic, morphological, and biological traits has resulted in the recognition of different lineages within taxa. One of the most striking differences in the "temperate" and "tropical" lineages of R. sanguineus (s.l.) is the vector competenc...
Solute carriers affect Anopheles stephensi survival and Plasmodium berghei infe...
Couto, J.; Antunes, S.; Pinheiro-Silva, R.; Do Rosário, V.; De La Fuente, J.; Domingos, A.Malaria is caused by mosquito-borne Plasmodium spp. parasites that must infect and survive within mosquito salivary glands (SGs) prior to host transmission. Recent advances in transcriptomics and the complete genome sequencing of mosquito vectors have increased our knowledge of the SG genes and proteins involved in pathogen infection and transmission. Membrane solute carriers are key proteins involved in drug t...
Reduction of mosquito survival in mice vaccinated with Anopheles stephensi gluc...
Couto, J.; Antunes, S.; Ferrolho, J.; De La Fuente, J.; Domingos, A.Despite the fact that recent efforts to control/eradicate malaria have contributed to a significant decrease in the number of cases and deaths, the disease remains a global health challenge. Vaccines based on mosquito salivary gland antigens are a potential approach for reducing vector populations and malaria parasites. The Anopheles AGAP007752 gene encodes for a glucose transporter that is upregulated during P...