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The Complexities of Canine Monocytic Ehrlichiosis

Ferrolho, Joana; Antunes, Sandra; Vilhena, Hugo; Anastácio, Sofia; Ramalho de Sousa, Sérgio; Frouco, Gonçalo; Ferreira, Bárbara; Domingos, Ana

Funding Information: This review was funded by the Portuguese Foundation for Science and Technology (FCT), projects UI/00772 and SFRH/122894/2016. Publisher Copyright: © 2025 by the authors.; Canine monocytic ehrlichiosis (CME) is a highly infectious disease with zoonotic potential. Ehrlichia canis, the causative agent, is primarily transmitted by Rhipicephalus sanguineus. Tick infestation and tick-borne diseas...


Molecular Survey of Anaplasmataceae Agents, Rickettsia spp., Bartonella spp., a...

Sanches, Gustavo Seron; Rodrigues, Luísa; Torrejón, Estefania; Bassini-Silva, Ricardo; Calchi, Ana Cláudia; Lee, Daniel Antônio Braga

308119/2022-3]), and Pro-Reitoria de Pesquisa da UNESP (Edital 12/2022-Projeto 4293). G.S.S. received a post-doctoral fellowship from Pro-Reitoria de Pesquisa da UNESP. Publisher Copyright: © 2025 by the authors.; Bats and their ectoparasites play a crucial role in understanding the ecology and transmission of vector-borne pathogens, yet these dynamics remain poorly studied in Portugal. This study aimed to inve...


Investigation of genes expression of the JAK/STAT signalling pathway and AMPs i...

Szczotko, Magdalena; Antunes, Sandra; Domingos, Ana; Dmitryjuk, Małgorzata

Funding Information: This research was supported by the Science Development Fund of the University of Warmia and Mazury in Olsztyn, Poland [No.12.610.012-110]. Funding Information: Authors would like to thank to Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia for funds to GHTM - UID/04413/2020 and LA-REAL \u2013 LA/P/0117/2020. Publisher Copyright: © The Author(s) 2025.; Multicellular animals need to cont...


Update on tick-borne rickettsioses in mainland Portugal

Moerbeck, Leonardo; Parreira, Ricardo; Seixas, Gonçalo; Velez, Rita; Domingos, Ana; Antunes, Sandra

Funding Information: The authors acknowledge the financial support from Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (FCT) through the PhD scholarship 2022.14376.BD awarded to Leonardo Moerbeck. Additionally, we deeply appreciate Dr. Ana Sofia Santos for her invaluable support, manuscript review and expertise in tick surveillance during the field campaigns. We also extend our gratitude to the administr...


Turning a vulnerability into a strength

Balau, Ana; Sobral, Daniel; Medeiros, Márcia; Antunes, Sandra; de Carvalho, Maria Duarte; Morais, Inês; Carvalho, Filomena; Gomes, João Paulo

Malaria remains a global health challenge and despite the considerable progress made in the mortality rate, the 2025 target of the Global Technical Strategy 2016–2030 is still far from being reached. New strategies to improve patient management, prevent severe cases, and reduce deaths, are urgently needed. Exploring interactions between the malaria parasite and host red blood cells (RBCs) offers opportunities t...


Ticks and Tick-Borne Pathogens Circulating in Peri-Domestic Areas in Mainland P...

Moerbeck, Leonardo; Parreira, Ricardo; Szczotko, Magdalena; Seixas, Gonçalo; Velez, Rita; Dmitryjuk, Małgorzata; Santos, Ana Sofia; Domingos, Ana

Funding Information: The authors would like to acknowledge the support given by the administrative and technical staff of Tapada Nacional de Mafra, Funda\u00E7\u00E3o Mata do Bussaco and Parque Ger\u00EAs-Peneda, and also Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia for funds to GHTM-UID/04413/2020 and LA-REAL\u2013LA/P/0117/2020. Funding Information: L.M. is a recipient of a Ph.D. grant supported by F...


A small proportion of Zebu genetic background in crossbred calves may not be en...

Azevedo, Bianca Tainá; de Oliveira, Henrique Nunes; Katiki, Luciana Morita; Filho, Anibal Eugênio Vercesi; Domingos, Ana Gonçalves; Antunes, Sandra

2019/22675-6) and the Institute of Animal Science (APTA-SAA). AMG Ibelli is recipient of a productivity fellowship from CNPq. Publisher Copyright: © 2024 Elsevier B.V.; The main objective of cattle breeders in tropical and subtropical regions is to acquire animals with taurine-productive traits adapted to the broad weather range of these regions. However, one of the main challenges on using taurine genetics in ...


Tick-Borne pathogens and defensin genes expression

Szczotko, Magdalena; Antunes, Sandra; Domingos, Ana; Kubiak, Katarzyna; Dmitryjuk, Małgorzata

Funding Information: This research was supported by the Science Development Fund of the University of Warmia and Mazury in Olsztyn, Poland [No.12.610.012-110]. Publisher Copyright: © 2024 The Authors; The immune system of ticks, along with that of other invertebrates, is comparatively simpler than that of vertebrates, relying solely on innate immune responses. Direct antimicrobial defence is provided by the syn...


Differential Gene Expression of Malaria Parasite in Response to Red Blood Cell-...

Balau, Ana; Sobral, Daniel; Abrantes, Patrícia; Santos, Inês; Mixão, Verónica; Gomes, João Paulo; Antunes, Sandra; Arez, Ana Paula

Innovative strategies to control malaria are urgently needed. Exploring the interplay between Plasmodium sp. parasites and host red blood cells (RBCs) offers opportunities for novel antimalarial interventions. Pyruvate kinase deficiency (PKD), characterized by heightened 2,3-diphosphoglycerate (2,3-DPG) concentration, has been associated with protection against malaria. Elevated levels of 2,3-DPG, a specific ma...


Tick Vaccines and Concealed versus Exposed Antigens

Antunes, Sandra; Domingos, Ana

Funding Information: The authors would like to thank FCT for funding the R&D Centre, Global Health and Tropical Medicine (GHTM—UID/04413/2020). Publisher Copyright: © 2023 by the authors.; Anti-tick vaccines development mainly depends on the identification of suitable antigens, which ideally should have different features. These should be key molecules in tick biology, encoded by a single gene, expressed across...


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