47 documents found, page 1 of 5
Height Benefit of GnRH Agonists After Age 8 in a Portuguese Cohort of Central P...
Castro, C; Espada, F; Leite, AL; Antunes, A; Robalo, B; Amaral, D; Galo, E; Castro, S; Ferreira, S; Limbert, CObjective: Idiopathic central precocious puberty (iCPP) is common in paediatric endocrinology. Gonadotropin-releasing hormone agonists (GnRHa) are safe, but the effect on final height and the ideal timing for treatment remains controversial. This study aims to assess the effectiveness of GnRHa on growth outcomes in girls with iCPP treated before and after the age of 8 years old. Design and patients: This retros...
Do GnRH Agonists Really Increase Body Weight Gain? Evaluation of a Multicentric...
Leite, AL; Galo, E; Antunes, A; Robalo, B; Amaral, D; Espada, F; Castro, S; Simões Dias, S; Limbert, CIntroduction: There are several concerns associated with gonadotropin-releasing hormone agonist (GnRHa) treatment for central precocious puberty (CPP), such as obesity and changes in body mass index (BMI). We aimed to investigate whether any anthropometric differences exist and if they persist over time. Methods: We conducted an observational study of Portuguese children (both sexes) diagnosed with CPP between ...
The Impact of COVID-19 on Rare and Complex Connective Tissue Diseases: the Expe...
Talarico, R; Aguilera, S; Alexander, T; Amoura, Z; Antunes, A; Arnaud, L; Avcin, T; Beretta, L; Bombardieri, S; Burmester, G; Cannizzo, S; Cavagna, LDuring the COVID-19 pandemic, the need to provide high-level care for a large number of patients with COVID-19 has affected resourcing for, and limited the routine care of, all other conditions. The impact of this health emergency is particularly relevant in the rare connective tissue diseases (rCTDs) communities, as discussed in this Perspective article by the multi-stakeholder European Reference Network on Ra...
Expression of HLA-DR in Cytotoxic T Lymphocytes: A Validated Predictive Biomark...
Saraiva, DP; Azeredo-Lopes, S; Antunes, A; Salvador, R; Borralho, P; Assis, B; Pereira, IL; Seabra, Z; Negreiros, I; Jacinto, A; Braga, S; Cabral, MGNeoadjuvant chemotherapy (NACT) is common in breast cancer (BC) treatment, though more than half of the patients lack an effective response. Therefore, new predictive biomarkers and alternative therapies are crucial. Previously, we proposed HLA-DR-expressing cytotoxic T lymphocytes (CTLs) as a potential biomarker of the response to NACT. To validate this observation and further investigate these cells, 202 BC p...
Putative antimicrobial peptides of the posterior salivary glands from the cepha...
Almeida, D; Domínguez-Pérez, D; Matos, A; Agüero-Chapin, G; Osorio, H; Vasconcelos, V; Campos, A; Antunes, ACephalopods, successful predators, can use a mixture of substances to subdue their prey, becoming interesting sources of bioactive compounds. In addition to neurotoxins and enzymes, the presence of antimicrobial compounds has been reported. Recently, the transcriptome and the whole proteome of the Octopus vulgaris salivary apparatus were released, but the role of some compounds—e.g., histones, antimicrobial pep...
A draft genome sequence of the elusive giant squid, Architeuthis dux
Fonseca, RR; Couto, A; Machado, AM; Brejova, B; Albertin, CB; Silva, F; Gardner, P; Baril, T; Hayward, A; Campos, A; Ribeiro, ÂM; Barrio-Hernandez, IBackground: The giant squid (Architeuthis dux; Steenstrup, 1857) is an enigmatic giant mollusc with a circumglobal distribution in the deep ocean, except in the high Arctic and Antarctic waters. The elusiveness of the species makes it difficult to study. Thus, having a genome assembled for this deep-sea-dwelling species will allow several pending evolutionary questions to be unlocked. Findings: We present a dra...
Shotgun Proteomics of Ascidians Tunic Gives New Insights on Host-Microbe Intera...
Matos, A; Domínguez-Pérez, D; Almeida, D; Aguëro-Chapin, G; Campos, A; Osorio, H; Vasconcelos, V; Antunes, AAscidians are marine invertebrates associated with diverse microbial communities, embedded in their tunic, conferring special ecological and biotechnological relevance to these model organisms used in evolutionary and developmental studies. Next-generation sequencing tools have increased the knowledge of ascidians' associated organisms and their products, but proteomic studies are still scarce. Hence, we explor...
CYP21A2 Gene Pathogenic Variants: A Multicenter Study on Genotype-Phenotype Cor...
Santos-Silva, R; Cardoso, R; Lopes, L; Fonseca, M; Espada, F; Sampaio, L; Brandão, C; Antunes, A; Bragança, G, et al.BACKGROUND: Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is an autosomal recessive disorder characterized by 3 overlapping phenotypes: salt-wasting (SW), simple virilizing (SV), and non-classic (NC). We aimed at conducting a nationwide genotype description of the CAH pediatric patients and to establish their genotype-phenotype correlation. METHODS: CAH patients were recruited fr...
Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease
Gonçalves-Dias, C; Morello, J; Correia, MJ; Coelho, N; Antunes, A; Macedo, MP; Monteiro, E; Soto, K, et al.BACKGROUND: The recent growing evidence that the proximal tubule underlies the early pathogenesis of diabetic kidney disease (DKD) is unveiling novel and promising perspectives. This pathophysiological concept links tubulointerstitial oxidative stress, inflammation, hypoxia, and fibrosis with the progression of DKD. In this new angle for DKD, the prevailing molecular mechanisms on proximal tubular cells emerge ...
Characterization of the First Conotoxin from Conus ateralbus, a Vermivorous Con...
Neves, J; Imperial, J; Morgenstern, D; Ueberheide, B; Gajewiak, J; Antunes, A; Robinson, S; Espino, S; Watkins, M; Vasconcelos, V; Olivera, BConus ateralbus is a cone snail endemic to the west side of the island of Sal, in the Cabo Verde Archipelago off West Africa. We describe the isolation and characterization of the first bioactive peptide from the venom of this species. This 30AA venom peptide is named conotoxin AtVIA (δ-conotoxin-like). An excitatory activity was manifested by the peptide on a majority of mouse lumbar dorsal root ganglion neuro...