41 documents found, page 1 of 5
Trends in land cover and in pollen concentration of Quercus genus in Alentejo, ...
Galveias, Ana; Duarte, Ediclê; Raposo, Mauro; Costa, Maria João; Costa, Ana; Antunes, CéliaMediterranean forests dominated by Quercus species are of great ecological and economic value. The Quercus pollen season, peaking in April, varies in concentration due to geographical and climatic factors and has a remarkable allergenic potential. This study investigates Quercus trends in the Alentejo region of Portugal and examines the influence of meteorological parameters on DPC, PSD and SPIn, as well as the...
Assessing the Potential of 1,2,3-Triazole-Dihydropyrimidinone Hybrids against C...
Carreiro, Elisabete; Costa, Ana; Burke, Anthony; Antunes, Célia; Gastalho, Carlos; Pereira, Florbela; Lopez, Oscar; Fernández-Bolaños, José G.Combining the pharmacological properties of the 1,2,3-triazole and dihydropyrimidinone classes of compounds, two small families of mono- and di(1,2,3-triazole)-dihydropyrimidinone hybrids, A and B, were previously synthesized. The main objective of this work was to investigate the potential anti-Alzheimer effects of these hybrids. The inhibitory activities of cholinesterases (AChE and BuChE), antioxidant activi...
Chitosan- and chitosan-polaxamer 407 based nanoparticles: green nanotechnology ...
Carreiro, Elisabete; Antunes, Célia; Gastalho, C.; Craveiro, AlexandreThe chymotrypsin-like main protease (3CLpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for cleavage of two viral polyproteins into 16 nonstructural pro- teins. Its catalytic activity is critical for the life cycle of the SARS-CoV-2, since the inhibition of the 3CLpro can effectively block the whole replication of the virus. The 3CLpro has a bell- shaped activity-pH profile w...
Understanding Mineral Dust Through a Doctoral Alliance
Marenco, Franco; Amiridis, Vasilis; Costa, Maria João; Kandler, Konrad; Kazadzis, Stelios; Klose, Martina; Pérez García-Pando, Carlos; Ryder, ClaireWe present an example of how a doctoral network can bring together multidisciplinary expertise and novel scientific advances in atmospheric dust. This network (Dust-DN) has started operations and is a strategic alliance of high-profile partners, able to leverage unique facilities for atmospheric research and innovative space missions. The network aims to improve our understandings of dust processes and microphy...
Quercetin-1,2,3-Triazole Hybrids as Multifunctional Anti-Alzheimer's Agents
Carreiro, Elisabete; Costa, Ana; Antunes, Célia; Burke, AJ; Pinto, F.; Ernesto, S.; Rodrigues, B.The number of patients with Alzheimer’s disease (AD) continues to rise and, despite the efforts of researchers, there are still no effective treatments for this multifaceted disease. The main objective of this work was the search for multifunctional and more effective anti-Alzheimer agents. Herein, we report the evaluation of a library of quercetin-1,2,3-triazole hybrids (I–IV) in antioxidant, hydrogen peroxide...
Outdoor airborne allergens: Characterization, behavior and monitoring in Europe
Grewling, Lukasz; Ribeiro, Helena; Antunes, Célia; Apangu, Godfrey; Çelenk, Sevcan; Costa, Ana; Eguiluz-Garcia, Ibon; Galveias, Ana; Roldan, NestorAeroallergens or inhalant allergens, are proteins dispersed through the air and have the potential to induce allergic conditions such as rhinitis, conjunctivitis, and asthma. Outdoor aeroallergens are found predominantly in pollen grains and fungal spores, which are allergen carriers. Aeroallergens from pollen and fungi have seasonal emission patterns that correlate with plant pollination and fungal sporulation...
The impacts of land use on the prevalence of allergic sensitization to olive po...
Antunes, Célia; Belchior, Marisa; Galveias, Ana; Rodrigues Costa, AnaAllergic diseases are a serious public health problem mainly in industrialized countries. In Portugal, pollen allergy affects about 20% of the population, with grasses and olive trees being among the most allergenic. The growing increase in the cultivation of olive groves in Alentejo as well as its use as an ornamental plant may have an impact on exposure to allergens, which may influence the risk of sensitizat...
Seasonal particulate matter protein and lipid content: a preliminary study in É...
Custodio, Mariana; Galveias, Ana; Rodrigues Costa, Ana; Costa, Maria João; Antunes, CéliaThe PM existing in the atmosphere, is considered as one of the most harmful pollutants for human health and exposure to PM by inhalation, depending on its variable composition over the different seasons, can cause several inflammatory responses. However, there is little knowledge about the seasonal composition and its impacts on human respiratory health is not yet fully understood. The aim of this preliminary s...
Search for environmental allergens in indoor samples using molecular techniques
Marchã Pennha, Alexandra; Galveias, Ana; Antunes, Célia; Morais, Manuela; Rodrigues Costa, AnaIndoor air quality is one of the most important factors that significantly influence the life quality of the population. Indoor environments are characterized by several sources of pollution, and the health problems associated with bad indoor air quality have acquired high importance in recent years. The biological particles present in the indoor environment can be of various types between viruses and bacteria,...
THINK4JOBS Critical Thinking blended apprenticeships curricula
Mäkiö, Juho; Mäkiö, Elena; Pnevmatikos, Dimitriοs; Christodoulou, Panagiota; Payan Carreira, Rita; Georgiadou, Triantafyllia; Lithoxoidou, AngelikiThe current Report namely, the third Intellectual Output (IO3) describes 12 Critical Thinking (CT) blended apprenticeships curricula. The development of these curricula was enabled and enhanced through the training that was carried out for Higher Education (HE) Instructors and Labour Market Organisation (LMO) Tutors (IO2). In this training, the participants learned how to promote, develop, support, and assess c...