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The first full study of heavy metal(loid)s in western-European hedgehogs (Erina...

The western-European hedgehog (Erinaceus europaeus) is an insectivore with a wide distribution in Portugal and a potential tool for biomonitoring relevant One Health hazards, including heavy metal(loid)s’ pollution. The aim of this study was to positively contribute to the current knowledge about the metal(loid) pollution in Portugal. Forty-six hedgehogs (from rescue centres; with known provenance) were necrops...

Serological evidence of antibodies to Flaviviridae in wild birds in Portugal

Emerging infectious diseases are a major threat to biodiversity and an important public health issue. Flaviviruses are the cause of several emerging vector-borne zoonotic arboviruses whose distribution is currently increasing in Europe. The evidence that West Nile virus (WNV) circulates in resident and migratory species has implications for both animal and public health and should therefore be studied in depth....

High levels of heavy metal(loid)s related to biliary hyperplasia in hedgehogs (...

Heavy metal(loid) pollution of ecosystems is a current One Health problem. The liver is one of the most affected organs in cases of acute or chronic exposure to abnormal amounts of these substances, inducing histopathologic lesions. In order to assess the influence of heavy metal(loids), forty-five European hedgehogs (Erinaceus europaeus) were submitted to necropsy, and liver samples were collected for a routin...

Efeito de antioxidantes sobre os níveis de metalotioneínas em camundongos trata...

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; In this study, acute effects of mercury on mouse blood, kidneys and liver were evaluated. Mice received a single dose of mercuric chloride (HgCl2 - 4.6 mg/kg, subcutaneously) for three consecutive days. We investigated the possible beneficial effects of antioxidant therapy (N-acetylcysteine (NAC) and diphenyl diselenide (PhSe)2) comparing to sodium sa...

Efeito do disseleneto de difenila sobre a toxicidade induzida por cloreto de me...

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Mercury is a metal without physiological functions in human body and is toxic to human beings. This metal has many applications in industry and, therefore it is very important in occupational and environmental exposure. The toxicity of mercury depends on the form of the metal and can affect several organs, such as brain, kidney and liver. In addition,...

Hematology and serum biochemistry values of free-ranging Iberian wolves (Canis ...

Hematology and serum biochemistry are important tools in assessing the health and physiological status of wildlife populations. Nevertheless, studies on free-ranging wolves (Canis lupus) are scarce, and no reference values are available neither for Iberian wolves nor for wolves captured with leghold snares. We report 37 hematology and serum biochemistry variables obtained from 26 free-ranging Iberian wolves cap...

Assessment of the exposure to heavy metals in Griffon vultures (Gyps fulvus) fr...

A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-de...

Introduction: The activation of the phosphoinositide 3-kinase (PI3K)/AKT signalling pathway is one the most frequent genetic events in breast cancer, consequently the development of PI3K inhibitors has attracted much attention. Here we evaluate the effect of PI3K inhibition on global gene expression in breast cancer cells. Methods: We used a range of methodologies that include in silico compound analysis, in vi...

Biomonitoring of heavy metals (Cd, Hg, and Pb) and metalloid (As) with the Port...